The critical role of the vasculature and its repair in neurological disease states is beginning
to emerge particularly for stroke, dementia, epilepsy, Parkinson's disease, tumors and …

Neural stem cells (NSCs) play vital roles in brain homeostasis and exhibit a broad repertoire
of potentially therapeutic actions following neurovascular injury. One such injury is stroke, a …

The brain vasculature has been increasingly recognized as a key player that directs brain
development, regulates homeostasis, and contributes to pathological processes. Following …

Angiogenesis, the growth of new blood vessels, is a natural defense mechanism helping to
restore oxygen and nutrient supply to the affected brain tissue following an ischemic stroke …

No treatment currently exists to restore lost neurological function after stroke. A growing
number of studies highlight the potential of stem cell transplantation as a novel therapeutic …

Ischemic stroke remains one of most common causes of death and disability worldwide.
Stroke triggers a cascade of events leading to rapid neuronal damage and death …

Clinical treatments for ischemic stroke are limited. Neural stem cell (NSC) transplantation
can be a promising therapy. Clinically, ischemia and subsequent reperfusion lead to …

Background: Blood–brain barrier permeability (BBBp) is a key process involved in ischemic
stroke pathophysiology. However, there is a lack of consensus on how BBBp evolves after …

Vascular endothelial growth factor (VEGF) is currently considered a potential pharmacologic
agent for stroke therapy because of its strong neuroprotective and angiogenic capacities …

Recent developments in our understanding of the pathophysiological events that follow
acute ischaemic stroke suggest an important role for angiogenesis which, through new …