Sepsis arises from diverse and incompletely understood dysregulated host response
processes following infection that leads to life-threatening organ dysfunction. Here we …

To define the cellular composition and architecture of cutaneous squamous cell carcinoma
(cSCC), we combined single-cell RNA sequencing with spatial transcriptomics and …

Metabolic-associated fatty liver disease (MAFLD) represents a spectrum of disease states
ranging from simple steatosis to non-alcoholic steatohepatitis (NASH). Hepatic …

Cellular metabolism regulates immune cell activation, differentiation and effector functions,
but current metabolic approaches lack single-cell resolution and simultaneous …

High-dimensional approaches have revealed heterogeneity amongst dendritic cells (DCs),
including a population of transitional DCs (tDCs) in mice and humans. However, the origin …

Microglia, the specialized innate immune cells of the CNS, play crucial roles in neural
development and function. Different phenotypes and functions have been ascribed to rodent …

High-dimensional mass and flow cytometry (HDCyto) experiments have become a method
of choice for high-throughput interrogation and characterization of cell populations. Here, we …

There is an agreement in the field that interlaboratory reproducibility of flow cytometry
measurements as well as the whole studies might be improved by a consensual use of …

Understanding the mechanisms of HIV tissue persistence necessitates the ability to visualize
tissue microenvironments where infected cells reside; however, technological barriers limit …

Mass cytometry, or Cytometry by Time-Of-Flight, is a powerful new platform for high-
dimensional single-cell analysis of the immune system. It enables the simultaneous …