The absorption of oral drugs is frequently plagued by significant variability with potentially
serious therapeutic consequences. The source of variability can be traced back to …

The simultaneous intake of food and drugs can have a strong impact on drug release,
absorption, distribution, metabolism and/or elimination and consequently, on the efficacy …

Developing a mechanistic understanding of the impact of food structure and composition on
human health has increasingly involved simulating digestion in the upper gastrointestinal …

Food protein-derived bioactive peptides are recognized as valuable ingredients of functional
foods and/or nutraceuticals to promote health and reduce the risk of chronic diseases …

Introduction: Physiological pH and chemical pKa are two sides of the same coin in defining
the ionization of a drug in the human body. The Henderson-Hasselbalch equation and pH …

Although oral drug delivery is the preferred administration route and has been used for
centuries, modern drug discovery and development pipelines challenge conventional …

Oral administration is the most common route of drug delivery. The absorption of a drug from
the gut into the bloodstream involves disintegration of the solid dosage form, dissolution of …

Growing evidence suggests the importance of the small intestinal bacteria in the diet–host–
microbiota dialogue in various facets of health and disease. Yet, this body site is still poorly …

The availability of in vitro tools that are constructed on the basis of a detailed knowledge of
key aspects of gastrointestinal (GI) physiology and their impact on formulation performance …

Many concepts of oral drug delivery are based on our comprehension of human
gastrointestinal physiology. Unfortunately, we tend to oversimplify the complex interplay …