Recent progress in engineering highly promising biocatalysts has increasingly involved
machine learning methods. These methods leverage existing experimental and simulation …

Enzymes can be engineered at the level of their amino acid sequences to optimize key
properties such as expression, stability, substrate range, and catalytic efficiency─ or even to …

Thermostability is an essential requirement for the use of enzymes in the bioindustry. Here,
we compare different protein stabilization strategies using a challenging target, a stable …

Designing efficient enzymes is a formidable challenge at the forefront of modern
biocatalysis. Here, we review recent developments in the field and illustrate how the …

White-rot fungi secrete a repertoire of high-redox potential oxidoreductases to efficiently
decompose lignin. Of these enzymes, versatile peroxidases (VPs) are the most promiscuous …

Thermostable proteins find their use in numerous biomedical and biotechnological
applications. However, the computational design of stable proteins often results in single …

The development and implementation of sustainable catalytic technologies is key to
delivering our net‐zero targets. Here we review how engineered enzymes, with a focus on …

Mutations in a protein active site can lead to dramatic and useful changes in protein activity.
The active site, however, is sensitive to mutations due to a high density of molecular …

White-rot fungi secrete an impressive repertoire of high-redox potential laccases (HRPLs)
and peroxidases for efficient oxidation and utilization of lignin. Laccases are attractive …

Covering: 2015 up to July 2021 The market for cosmetics is consumer driven and the desire
for green, sustainable and natural ingredients is increasing. The use of isolated enzymes …