Parkinson disease (PD) is a progressive neurodegenerative disease that affects peripheral
organs as well as the central nervous system and involves a fundamental role of …

The incidence of neurodegenerative diseases has shown an increasing trend. These
conditions typically cause progressive functional disability. Identification of robust …

Neurite orientation dispersion and density imaging (NODDI) uses a three‐compartment
model to probe brain tissue microstructure, whereas free‐water (FW) imaging models two …

There has been an increasing prevalence of neurodegenerative diseases with the rapid
increase in aging societies worldwide. Biomarkers that can be used to detect pathological …

Diffusion tensor imaging (DTI) allows measuring fractional anisotropy and similar
microstructural indices of the brain white matter. Lower than normal fractional anisotropy as …

Parkinson's disease is a heterogeneous disorder with both motor and non-motor symptoms
that contribute to functional impairment. To develop effective, disease modifying treatments …

There is a pressing need for disease-modifying therapies in patients suffering from
neurodegenerative diseases, including Parkinson's disease (PD). However, these disorders …

The pathophysiology of all investigated tremors involves the cerebello-thalamo-cortical
pathway, and clinical and pathophysiological features overlap among tremor disorders. We …

Background Degeneration of the substantia nigra (SN) may contribute to levodopa‐induced
dyskinesia (LID) in Parkinson's disease (PD), but the exact characteristics of SN in LID …

Highlights Imaging of the dopamine transporter (DAT)(in particular using 11C-or 18F-PE2I)
most reliably and precisely measures neurodegeneration of the dopaminergic system in …