The continued threat of emerging flaviviruses

TC Pierson, MS Diamond - Nature microbiology, 2020 - nature.com
Flaviviruses are vector-borne RNA viruses that can emerge unexpectedly in human
populations and cause a spectrum of potentially severe diseases including hepatitis …

Molecular insights into the flavivirus replication complex

K Van den Elsen, JP Quek, D Luo - Viruses, 2021 - mdpi.com
Flaviviruses are vector-borne RNA viruses, many of which are clinically relevant human viral
pathogens, such as dengue, Zika, Japanese encephalitis, West Nile and yellow fever …

[HTML][HTML] TMEM41B is a pan-flavivirus host factor

HH Hoffmann, WM Schneider, K Rozen-Gagnon… - Cell, 2021 - cell.com
Flaviviruses pose a constant threat to human health. These RNA viruses are transmitted by
the bite of infected mosquitoes and ticks and regularly cause outbreaks. To identify host …

Structural and biochemical characterization of the nsp12-nsp7-nsp8 core polymerase complex from SARS-CoV-2

Q Peng, R Peng, B Yuan, J Zhao, M Wang, X Wang… - Cell reports, 2020 - cell.com
The ongoing global pandemic of coronavirus disease 2019 (COVID-19) has caused a huge
number of human deaths. Currently, there are no specific drugs or vaccines available for this …

Endoplasmic reticulum chaperones in viral infection: therapeutic perspectives

E Kohli, S Causse, V Baverel, L Dubrez… - Microbiology and …, 2021 - Am Soc Microbiol
Viruses are intracellular parasites that subvert the functions of their host cells to accomplish
their infection cycle. The endoplasmic reticulum (ER)-residing chaperone proteins are …

A global lipid map defines a network essential for Zika virus replication

HC Leier, JB Weinstein, JE Kyle, JY Lee… - Nature …, 2020 - nature.com
Zika virus (ZIKV), an arbovirus of global concern, remodels intracellular membranes to form
replication sites. How ZIKV dysregulates lipid networks to allow this, and consequences for …

Genome-wide CRISPR screen identifies RACK1 as a critical host factor for flavivirus replication

B Shue, AI Chiramel, B Cerikan, TH To… - Journal of …, 2021 - Am Soc Microbiol
Cellular factors have important roles in all facets of the flavivirus replication cycle.
Deciphering viral-host protein interactions is essential for understanding the flavivirus life …

Cellular ESCRT components are recruited to regulate the endocytic trafficking and RNA replication compartment assembly during classical swine fever virus infection

C Liu, Y Liu, J Zhou, X Chen, H Chen, J Hu… - PLoS …, 2022 - journals.plos.org
As the important molecular machinery for membrane protein sorting in eukaryotic cells, the
endosomal sorting and transport complexes (ESCRT-0/I/II/III and VPS4) usually participate …

The molecular interactions of ZIKV and DENV with the type-I IFN response

RC Coldbeck-Shackley, NS Eyre, MR Beard - Vaccines, 2020 - mdpi.com
Zika Virus (ZIKV) and Dengue Virus (DENV) are related viruses of the Flavivirus genus that
cause significant disease in humans. Existing control measures have been ineffective at …

Molecular surveillance of dengue virus in field-collected Aedes mosquitoes from Bhopal, central India: evidence of circulation of a new lineage of serotype 2

DK Sarma, L Rathod, S Mishra, D Das… - Frontiers in …, 2023 - frontiersin.org
Introduction Dengue fever is hyperendemic in several Southeast and South Asian countries,
including India, with all four serotypes (DENV 1–4) circulating at different periods and in …