Neutrophil elastase (NE) is a major inflammatory protease released by neutrophils and is
present in the airways of patients with cystic fibrosis (CF), chronic obstructive pulmonary …

Tetraspanins are molecular scaffolds that distribute proteins into highly organized
microdomains consisting of adhesion, signaling, and adaptor proteins. Many reports have …

Abstract α1-Antitrypsin deficiency (A1ATD) is an inherited disorder caused by mutations in
SERPINA1, leading to liver and lung disease. It is not a rare disorder but frequently goes …

Polymorphonuclear neutrophils are the first cells recruited to inflammatory sites and form the
earliest line of defense against invading microorganisms. Neutrophil elastase, proteinase 3 …

Chronic lung disease determines the morbidity and mortality of cystic fibrosis (CF) patients.
The pulmonary immune response in CF is characterized by an early and non-resolving …

Neutrophil elastase (NE) activity is increased in bronchiectasis and may play a role in this
condition. We wished to determine the effect of AZD9668, a selective oral inhibitor of NE …

Airway mucus hyperproduction is a common feature of chronic airway diseases such as
severe asthma, chronic obstructive pulmonary disease and cystic fibrosis, which are closely …

Interleukin-8 (IL-8) is a neutrophil chemokine that is encoded on the CXCL8 gene. Normally
CXCL8 expression is repressed due to histone deacetylation, octamer-1 binding to the …

Epithelial permeability is a hallmark of mucosal inflammation, but the molecular mechanisms
involved remain poorly understood. A key component of the epithelial barrier is the apical …

Chronic inflammatory lung diseases such as cystic fibrosis and emphysema are
characterized by higher‐than‐normal levels of pulmonary proteases. While these enzymes …