Over the last decade, a dual character of cell response to oxidative stress, eustress versus
distress, has become increasingly recognized. A growing body of evidence indicates that …

Parkinson's disease (PD) is a movement disorder associated with severe loss of mainly
dopaminergic neurons in the substantia nigra. Pathological hallmarks include Lewy bodies …

Albumin, a major transporting protein in the blood, is the main target of modification that
affects the binding of drugs to Sudlow's site I and II. These modification of serum protein …

The use of mass spectrometry coupled with chemical cross-linking of proteins has become a
powerful tool for proteins structure and interactions studies. Unlike structural analysis of …

Significance: The systematic investigation of oxidative modification of proteins by reactive
oxygen species started in 1980. Later, it was shown that reactive nitrogen species could also …

Renal diseases are a global health concern, and nearly 24% of kidney disease patients are
overweight or obese. Particularly, increased body mass index has been correlated with …

Neutrophil myeloperoxidase (MPO) plays an important role in protecting the body against
infections. MPO products–hypohalous acids and phenoxyl radicals–are strong oxidants that …

Novel cross-links between an oxidized histidine and intact histidine, lysine, or cysteine
residues were discovered and characterized from high-molecular weight (HMW) fractions of …

In this study, we assessed the oxidative damage occurring in plasma proteins when human
blood was exposed to inflammatory concentrations of hypochlorous acid (HOCl). We used …

Protein insolubilization, cross-linking and aggregation are considered critical to the
development of lens opacity in cataract. However, the information about the presence of …