Once damaged, articular cartilage has a limited potential to repair. Clinically, a repair tissue
is formed, yet, it is often mechanically inferior fibrocartilage. The use of monolayer expanded …

Research into the pathophysiology of osteoarthritis (OA) has focused on cartilage and peri-
articular bone, but there is increasing recognition that OA affects all of the joint tissues …

Osteoarthritis of the knee is a complex peripheral joint disorder with multiple risk factors. The
molecular basis of osteoarthritis has been generally accepted; however, the exact …

Damage‐associated molecular patterns (DAMPs) include endogenous intracellular
molecules released by activated or necrotic cells and extracellular matrix (ECM) molecules …

Osteoarthritis (OA) involves all the structures of the joint. How the disease is initiated and
what factors trigger the disease process remain unclear, although the mechanical …

The preservation of articular cartilage depends on keeping the cartilage architecture intact.
Cartilage strength and function depend on both the properties of the tissue and on their …

The predominant proteoglycan present in cartilage is the large chondroitin sulfate
proteoglycan 'aggrecan'. Following its secretion, aggrecan self-assembles into a …

Osteoarthritis (OA) is currently defined by the American College of Rheumatology as a
“heterogeneous group of conditions that leads to joint symptoms and signs which are …

Decorin (DCN) is a ubiquitous proteoglycan comprised of a core protein attached to a single
dermatan/chondroitin sulphate glycosaminoglycan chain. It may play a role in regulation of …

Alarmins (also known as danger signals) are endogenous molecules that are released to
the extracellular milieu after infection or tissue damage. Extracellular alarmins interact with …