Pancreatic cancer (PC), an important cause of cancer-related deaths worldwide, is one of
the most malignant cancers characterized by a dismal prognosis. Circular RNAs (circRNAs) …

Abstract The KDM4 subfamily H3K9 histone demethylases are epigenetic regulators that
control chromatin structure and gene expression by demethylating histone H3K9, H3K36 …

Objectives In this study we describe the tumor microenvironment, the signaling pathways
and genetic alterations associated with the presence or absence of CD8+ T-cell infiltration in …

Background/Aims: We aimed to study the involvement of circZMYM2 (hsa_circ_0099999) in
pancreatic cancer (PC) cell proliferation, apoptosis and invasion and to figured out the …

Histone modifications (HMs) contribute to maintaining genomic stability, transcription, DNA
repair, and modulating chromatin in cancer cells. Furthermore, HMs are dynamic and …

The chromatin structure of the mammalian genome must facilitate both precisely-controlled
DNA replication together with tightly-regulated gene transcription. This necessarily involves …

Aims: Acute myeloid leukemia (AML) is an aggressive hematologic neoplasm, in which
relapse due to drug resistance is the main cause for treatment failure and the disease …

Aberrant metabolism is arising interest in the scientific community not only because of the
role it plays in the development and establishment of the tumor mass but also the possibility …

Hereditary cancers with cancer-predisposing mutations represent unique models of human
oncogenesis, as a driving oncogenic event is present in germline. Currently, there are no …

Purpose: Triple-negative breast cancer (TNBC) patients of various ethnic groups often have
discrete clinical presentations and outcomes. Women of African descent have a …