Double-stranded RNA (dsRNA) is associated with most viral infections—it either constitutes
the viral genome (in the case of dsRNA viruses) or is generated in host cells during viral …

Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus
infection, mediating the transcriptional induction of type I interferons and other genes that …

Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are RNA sensor molecules that
play essential roles in innate antiviral immunity. Among the three RLRs encoded by the …

RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated
protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of …

Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression in
the immune system. Studies have shown that lncRNAs are expressed in a highly lineage …

Efforts to understand autoimmunity have been pursued relentlessly for several decades. It
has become apparent that the immune system evolved multiple mechanisms for controlling …

Detection of double-stranded RNAs (dsRNAs) is a central mechanism of innate immune
defense in many organisms. We here discuss several families of dsRNA-binding proteins …

CRISPR-Cas9 is a versatile genome editing technology for studying the functions of genetic
elements. To broadly enable the application of Cas9 in vivo, we established a Cre …

Dissection of the genetic basis of Aicardi–Goutières syndrome has highlighted a
fundamental link between nucleic acid metabolism, innate immune sensors and type I …

Aberrant activation of innate immune receptors can cause a spectrum of immune disorders,
such as Aicardi-Goutières syndrome (AGS). One such receptor is MDA5, a viral dsRNA …