[HTML][HTML] Therapeutic advances of miRNAs: A preclinical and clinical update

C Chakraborty, AR Sharma, G Sharma… - Journal of advanced …, 2021 - Elsevier
Background miRNAs, a class of small endogenous RNAs, are one of the essential
biopharmaceuticals which are in commercial spans as next-generation medicine in recent …

miRNAs as biomarkers and therapeutic targets in non-small cell lung cancer: current perspectives

M Florczuk, A Szpechcinski… - Targeted oncology, 2017 - Springer
Lung cancer is the most common cancer worldwide. Up to 85% of lung cancer cases are
diagnosed as non-small cell lung cancer (NSCLC). The effectiveness of NSCLC treatment is …

MiRNA-based therapeutics for lung cancer

M Wu, G Wang, W Tian, Y Deng… - Current pharmaceutical …, 2017 - ingentaconnect.com
Background: miRNA, a small non-coding RNA molecule containing about 22 nucleotides,
functions in RNA silencing and post-transcriptional regulation of gene expression. With …

microRNAs as novel therapeutics in cancer

G Romano, M Acunzo, P Nana-Sinkam - Cancers, 2021 - mdpi.com
Simple Summary Over the last few years, we have witnessed incredible advancements in
anti-tumor drug development. microRNAs, a class of small non-coding RNAs dysregulated …

MiR-29a: a potential therapeutic target and promising biomarker in tumors

J Wang, Q Zhang, D Wang, W Yan, H Sha… - Bioscience …, 2018 - portlandpress.com
MiRNAs, small non-coding RNA molecules, were recognized to be associated with the
incidence and development of diverse neoplasms. MiRNAs were small non-coding RNAs …

Exosomal microRNA in pancreatic cancer diagnosis, prognosis, and treatment: from bench to bedside

MH Uddin, MN Al-Hallak, PA Philip, RM Mohammad… - Cancers, 2021 - mdpi.com
Simple Summary Pancreatic cancer is the fourth leading cause of cancer death in the United
States and over 90% of the patients suffer from pancreatic ductal adenocarcinoma (PDAC) …

[HTML][HTML] MicroRNAs associated with therapy of non-small cell lung cancer

J Lu, Y Zhan, J Feng, J Luo, S Fan - International Journal of …, 2018 - ncbi.nlm.nih.gov
Background & Objective: The incidence of non-small cell lung cancer (NSCLC) has been
rising over the past several decades. Despite various therapeutic regimens and modern …

Recent updates on the resistance mechanisms to epidermal growth factor receptor tyrosine kinase inhibitors and resistance reversion strategies in lung cancer

SK Tripathi, K Pandey… - Medicinal Research …, 2020 - Wiley Online Library
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) have led to a
substantial improvement in the prognosis of lung cancer patients by explicitly targeting the …

MicroRNAs as the critical regulators of tyrosine kinase inhibitors resistance in lung tumor cells

A Maharati, AS Zanguei, G Khalili-Tanha… - Cell Communication and …, 2022 - Springer
Lung cancer is the second most common and the leading cause of cancer related deaths
globally. Tyrosine Kinase Inhibitors (TKIs) are among the common therapeutic strategies in …

miR‐495 sensitizes MDR cancer cells to the combination of doxorubicin and taxol by inhibiting MDR1 expression

Z Zou, R Zou, D Zong, Y Shi, J Chen… - Journal of Cellular …, 2017 - Wiley Online Library
MDR1 is highly expressed in MDR A2780DX5 ovarian cancer cells, MDR SGC7901R
gastric cancer cells and recurrent tumours. It pumps cytoplasmic agents out of cells, leading …