A cell's fate: an overview of the molecular biology and genetics of apoptosis

GC Cavalcante, AP Schaan, GF Cabral… - International journal of …, 2019 - mdpi.com
Apoptosis is one of the main types of regulated cell death, a complex process that can be
triggered by external or internal stimuli, which activate the extrinsic or the intrinsic pathway …

The epidemiological impact of stis among general and vulnerable populations of the amazon region of Brazil: 30 years of surveillance

LFA Machado, RRS Fonseca, MAF Queiroz… - Viruses, 2021 - mdpi.com
Sexually transmitted infections (STIs) represent a worldwide public health problem and,
although many of them are curable, they continue to be neglected, especially in areas with a …

[HTML][HTML] Polymorphisms Influence the Expression of the Fas and FasL Genes in COVID-19

WR dos Santos Brito, WB de Brito… - International Journal of …, 2025 - mdpi.com
The apoptotic molecule Fas and its ligand FasL are involved in the process of T-lymphocyte
death, which may lead to lymphopenia, a characteristic of severe coronavirus disease 2019 …

IFNG +874A/T Polymorphism Among Asymptomatic HTLV-1-Infected Individuals Is Potentially Related to a Worse Prognosis

MAF Queiroz, VN Azevedo, ESG Amoras… - Frontiers in …, 2018 - frontiersin.org
HTLV-1 infections are persistent and frequently latent; however, productive infections trigger
different types of immunological responses that utilize cytokines to control infection. The …

Plasma Levels of sFas-sFasL and FASL Gene Expression Are Associated with Tuberculosis

IP Souza, ESG Amoras, FDM Sousa, PVNR Sousa… - Biomolecules, 2022 - mdpi.com
Apoptosis of macrophages infected by Mycobacterium tuberculosis via Fas-FasL is an
important immune mechanism against infection. This study investigated the association of …

Advances in the treatment of human T-cell lymphotropic virus type-I associated myelopathy

B Mashkani, M Jalili Nik, SA Rezaee… - Expert Review of …, 2023 - Taylor & Francis
ABSTRACT Introduction Nearly 2–3% of those 10 to 20 million individuals infected with the
Human T-cell lymphotropic virus type-1 (HTLV-1); are predisposed to developing HTLV-1 …

Influence of immunogenetic biomarkers in the clinical outcome of HTLV-1 infected persons

ACR Vallinoto, I Cayres-Vallinoto, MA Freitas Queiroz… - Viruses, 2019 - mdpi.com
Human T-lymphotropic virus 1, a member of the Retroviridae family, causes a neglected,
silent, persistent infection affecting circa 5 to 10 million people around the world, with …

A Fashi Lymphoproliferative Phenotype Reveals Non-Apoptotic Fas Signaling in HTLV-1-Associated Neuroinflammation

SM Menezes, FE Leal, T Dierckx, R Khouri… - Frontiers in …, 2017 - frontiersin.org
Human T-cell lymphotropic virus (HTLV)-1 was the first human retrovirus to be associated to
cancer, namely adult T-cell leukemia (ATL), but its pathogenesis remains enigmatic, since …

Simultaneous RNA quantification of human and retroviral genomes reveals intact interferon signaling in HTLV-1-infected CD4+ T cell lines

B Moens, C Pannecouque, G López, M Talledo… - Virology journal, 2012 - Springer
Background IFN-α contributes extensively to host immune response upon viral infection
through antiviral, pro-apoptotic, antiproliferative and immunomodulatory activities. Although …

HTLV‐1‐Associated Myelopathy/Tropical Spastic Paraparesis Is Not Associated with SNP rs12979860 of the IL‐28B Gene

ACR Vallinoto, BB Santana, KSG Sá… - Mediators of …, 2015 - Wiley Online Library
The present study investigated the association between the rs12979860 polymorphism in
the IL‐28B gene and HTLV‐1 infection as well as the development of HTLV‐1‐associated …