The orbitofrontal cortex and amygdala are involved in emotion and in motivation, but the
relationship between these functions performed by these brain structures is not clear. To …

Rewards are crucial objects that induce learning, approach behavior, choices, and
emotions. Whereas emotions are difficult to investigate in animals, the learning function is …

Although the orbitofrontal cortex (OFC) has been studied intensely for decades, its precise
functions have remained elusive. We recently hypothesized that the OFC contains a" …

Specialization and hierarchy are organizing principles for primate cortex, yet there is little
direct evidence for how cortical areas are specialized in the temporal domain. We measured …

Neuroscience research has exploded, with more than fifty thousand neuroscientists applying
increasingly advanced methods. A mountain of new facts and mechanisms has emerged …

The number of papers about the orbitofrontal cortex (OFC) has grown from 1 per month in
1987 to a current rate of over 50 per month. This publication stream has implicated the OFC …

Why does performing certain tasks cause the aversive experience of mental effort and
concomitant deterioration in task performance? One explanation posits a physical resource …

Orbitofrontal cortex (OFC) has long been known to play an important role in decision
making. However, the exact nature of that role has remained elusive. Here, we propose a …

Economic choice behavior entails the computation and comparison of subjective values. A
central contribution of neuroeconomics has been to show that subjective values are …

The orbitofrontal cortex represents the reward or affective value of primary reinforcers
including taste, touch, texture, and face expression. It learns to associate other stimuli with …