Neurofilament accumulations in amyotrophic lateral sclerosis patients' motor neurons impair axonal initial segment integrity

C Lefebvre-Omar, E Liu, C Dalle, BL d'Incamps… - Cellular and Molecular …, 2023 - Springer
Amyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease in
adults with no curative treatment. Neurofilament (NF) level in patient'fluids have recently …

Maturation of persistent and hyperpolarization-activated inward currents shapes the differential activation of motoneuron subtypes during postnatal development

SA Sharples, GB Miles - Elife, 2021 - elifesciences.org
The size principle underlies the orderly recruitment of motor units; however, motoneuron
size is a poor predictor of recruitment amongst functionally defined motoneuron subtypes …

[图书][B] Advanced neuromuscular exercise physiology

P Gardiner - 2024 - books.google.com
Advanced Neuromuscular Exercise Physiology, Second Edition, uses a mix of biochemistry,
molecular biology, neurophysiology, and muscle physiology to provide a synthesis of …

Structural preservation does not ensure function at sensory Ia–motoneuron synapses following peripheral nerve injury and repair

TM Rotterman, VV García, SN Housley… - Journal of …, 2023 - Soc Neuroscience
Injury that severs peripheral nerves often results in long-lasting motor behavioral deficits and
in reorganization of related spinal motor circuitry, neither of which reverse even after nerve …

Identification of candidate genes involved in Zika virus-induced reversible paralysis of mice

JD Morrey, V Siddharthan, H Wang, ALR Oliveira… - Scientific Reports, 2025 - nature.com
Zika virus (ZIKV) causes a variety of peripheral and central nervous system complications
leading to neurological symptoms such as limb weakness. We used a mouse model to …

Motor learning changes the axon initial segment of the spinal motoneuron

Y Wang, Y Chen, L Chen, BJ Herron… - The Journal of …, 2024 - Wiley Online Library
We are studying the mechanisms of H‐reflex operant conditioning, a simple form of learning.
Modelling studies in the literature and our previous data suggested that changes in the axon …

[HTML][HTML] Thalamic Neuron Resilience during Osmotic Demyelination Syndrome (ODS) Is Revealed by Primary Cilium Outgrowth and ADP-ribosylation factor-like …

J Gilloteaux, K De Swert, V Suain… - International journal of …, 2023 - mdpi.com
A murine osmotic demyelinating syndrome (ODS) model was developed through chronic
hyponatremia, induced by desmopressin subcutaneous implants, followed by precipitous …

M‐type potassium currents differentially affect activation of motoneuron subtypes and tune recruitment gain

SA Sharples, MJ Broadhead, JA Gray… - The Journal of …, 2023 - Wiley Online Library
The size principle is a key mechanism governing the orderly recruitment of motor units and
is believed to be dependent on passive properties of the constituent motoneurons. However …

Structural plasticity of axon initial segment in spinal cord neurons underlies inflammatory pain

Y Caspi, M Mazar, Y Kushnir, Y Mazor, B Katz, S Lev… - Pain, 2023 - journals.lww.com
Physiological or pathology-mediated changes in neuronal activity trigger structural plasticity
of the action potential generation site—the axon initial segment (AIS). These changes affect …

[HTML][HTML] Microfluidic Platforms Promote Polarization of Human-Derived Retinal Ganglion Cells That Model Axonopathy

AM Boal, NR McGrady, X Chamling… - … Vision Science & …, 2023 - iovs.arvojournals.org
Purpose: Axons depend on long-range transport of proteins and organelles which increases
susceptibility to metabolic stress in disease. The axon initial segment (AIS) is particularly …