Ceramides are involved in a variety of cellular processes and in disease. Their biological
functions are thought to depend on ceramides' unique biophysical properties, which …

Ceramides are a class of sphingolipids that are abundant in cell membranes. They are
important structural components of the membrane but can also act as second messengers in …

Apoptosis and autophagy are two evolutionarily conserved processes that maintain
homeostasis during stress. Although the two pathways utilize fundamentally distinct …

Different studies corroborate a role for ceramide synthases and their downstream products,
ceramides, in modulation of apoptosis and autophagy in the context of cancer. These …

Sphingolipids are comprised of a backbone sphingoid base that may be phosphorylated,
acylated, glycosylated, bridged to various headgroups through phosphodiester linkages, or …

This paper reviews the current knowledge on the various mechanisms for transbilayer, or flip-
flop, lipid motion in model and cell membranes, enzyme-assisted lipid transfer by flippases …

Ceramides are bioactive sphingolipids that support the structure of the plasma membrane
and mediate numerous cell-signaling events in eukaryotic cells. The finding that ceramides …

Recent evidence suggests that ceramide regulates stress signaling via reorganization of the
plasma membrane. The focus of this review will be to discuss the mechanism by which acid …

Insulin resistance is defined as a complex pathological condition of abnormal cellular and
metabolic response to insulin. Obesity and consumption of high-fat diet lead to ectopic …

Myristoylation corresponds to the irreversible covalent linkage of the 14-carbon saturated
fatty acid, myristic acid, to the N-terminal glycine of many eukaryotic and viral proteins. It is …