Functions of galanin, spexin and kisspeptin in metabolism, mood and behaviour

EG Mills, C Izzi-Engbeaya, A Abbara… - Nature Reviews …, 2021 - nature.com
The bioactive peptides galanin, spexin and kisspeptin have a common ancestral origin and
their pathophysiological roles are increasingly the subject of investigation. Evidence …

Emerging roles of NPQ/spexin in physiology and pathology

SY Lv, YC Zhou, XM Zhang, WD Chen… - Frontiers in …, 2019 - frontiersin.org
Spexin (SPX), also called neuropeptide Q (NPQ), is a novel endogenous neuropeptide.
Spexin gene and protein are widely expressed in central nervous system and peripheral …

[HTML][HTML] 30-Day spexin treatment of mice with diet-induced obesity (DIO) and type 2 diabetes (T2DM) increases insulin sensitivity, improves liver functions and …

PA Kolodziejski, N Leciejewska, A Chmurzynska… - Molecular and Cellular …, 2021 - Elsevier
Spexin (SPX) is a 14 aa peptide discovered in 2007 using bioinformatics methods. SPX
inhibits food intake and regulates lipid, and carbohydrate metabolism. Here, we evaluate the …

Different spexin level in obese vs normal weight children and its relationship with obesity related risk factors

M Behrooz, E Vaghef-Mehrabany… - Nutrition, Metabolism and …, 2020 - Elsevier
Background and aims Spexin (SPX) is a novel peptide recently discovered as an important
regulatory adipokine in obesity and related metabolic diseases. The aim of the current study …

Spexin alleviates hypertension, hyperuricaemia, dyslipidemia and insulin resistance in high fructose diet induced metabolic syndrome in rats via enhancing PPAR-ɣ …

MA Said, NY Nafeh, HA Abdallah - Archives of physiology and …, 2023 - Taylor & Francis
Spexin is a novel peptide implicated in obesity and energy homeostasis. The objective of the
current study was to evaluate the effect of spexin on blood pressure, insulin resistance, and …

The role of spexin in energy metabolism

X Sun, Z Yu, Y Xu, S Pu, X Gao - Peptides, 2023 - Elsevier
Spexin, also identified as neuropeptide Q (NPQ), is a 14 amino acid peptide discovered by
bioinformatic methods. It has a conserved structure in many species and is widely expressed …

Spexin improves adipose tissue inflammation and macrophage recruitment in obese mice

SE Gambaro, MG Zubiría, AP Giordano… - … et Biophysica Acta (BBA …, 2020 - Elsevier
Spexin (SPX) is a novel adipokine related to many metabolic effects, such as gastrointestinal
movements, insulin and glucose homeostasis, lipid metabolism and energy balance. This …

Spexin levels are associated with metabolic syndrome components

NM Al-Daghri, A Alenad, H Al-Hazmi, OE Amer… - Disease …, 2018 - Wiley Online Library
Background. Spexin (SPX) is a novel peptide that is implicated in obesity and related energy
homeostasis in animals and adult humans. Little is known about its role in adults' overall …

Spexin protects cardiomyocytes from hypoxia-induced metabolic and mitochondrial dysfunction

Y Liu, L Sun, L Zheng, M Su, H Liu, Y Wei, D Li… - Naunyn-Schmiedeberg's …, 2020 - Springer
Spexin (SPX) is a novel peptide with pleiotropic functions in adipose tissue including energy
balance adjustment, fatty acid uptake, and glucose homeostasis. SPX level is closely …

Galanin peptide family regulation of glucose metabolism

P Fang, M Yu, M Shi, P Bo, Z Zhang - Frontiers in Neuroendocrinology, 2020 - Elsevier
Recent preclinical and clinical studies have indicated that the galanin peptide family may
regulate glucose metabolism and alleviate insulin resistance, which diminishes the …