Posterior corneoscleral limbus: Architecture, stem cells, and clinical implications

GHF Yam, S Pi, Y Du, JS Mehta - Progress in Retinal and Eye Research, 2023 - Elsevier
The limbus is a transition from the cornea to conjunctiva and sclera. In human eyes, this thin
strip has a rich variation of tissue structures and composition, typifying a change from scleral …

Cascade of inflammatory, fibrotic processes, and stress-induced senescence in chronic GVHD-related dry eye disease

Y Ogawa, Y Kawakami, K Tsubota - International journal of molecular …, 2021 - mdpi.com
Ocular graft-versus-host disease (GVHD) is a major complication after allogeneic
hematopoietic stem cell transplantation. Ocular GVHD affects recipients' visual function and …

A proof-of-concept clinical trial using mesenchymal stem cells for the treatment of corneal epithelial stem cell deficiency

M Calonge, I Pérez, S Galindo, T Nieto-Miguel… - Translational …, 2019 - Elsevier
Ocular stem cell transplantation derived from either autologous or allogeneic donor
corneoscleral junction is a functional cell therapy to manage extensive and/or severe limbal …

Subconjunctival injection of mesenchymal stromal cells protects the cornea in an experimental model of GVHD

R Martínez-Carrasco, LI Sánchez-Abarca… - The ocular …, 2019 - Elsevier
Purpose To evaluate the therapeutic effect of subconjunctival injection of human
mesenchymal stromal cells (hMSCs) in the cornea of mice with graft versus host disease …

Stem cell-based therapeutic strategies for corneal epithelium regeneration

H Nosrati, Z Alizadeh, A Nosrati, K Ashrafi-Dehkordi… - Tissue and Cell, 2021 - Elsevier
Any significant loss of vision or blindness caused by corneal damages is referred to as
corneal blindness. Corneal blindness is the fourth most common cause of blindness …

Regenerative therapies in dry eye disease: from growth factors to cell therapy

AJ Villatoro, V Fernández, S Claros… - International Journal of …, 2017 - mdpi.com
Dry eye syndrome is a complex and insidious pathology with a high level of prevalence
among the human population and with a consequently high impact on quality of life and …

Keeping an 'eye'on ocular GVHD

JM Kezic, S Wiffen, M Degli-Esposti - Clinical and Experimental …, 2022 - Taylor & Francis
Ocular graft versus host disease (GVHD) is a common manifestation in patients undergoing
allogeneic haematopoietic stem cell transplantation (allo-HSCT). Ocular GVHD affects …

[PDF][PDF] Bone marrow cells differentiation into organ cells using stem cell therapy

YJ Yang, XL Li, Y Xue, CX Zhang… - Eur Rev Med …, 2016 - europeanreview.org
Bone marrow cells (BMC) are progenitors of bone, cartilage, skeletal tissue, the
hematopoiesis-supporting stroma and adipocyte cells. BMCs have the potential to …

Immunopathological mechanisms and clinical manifestations of ocular graft-versus-host disease following hematopoietic stem cell transplantation

RB Singh, W Cho, C Liu, A Naderi, PL Surico… - Bone Marrow …, 2024 - nature.com
Graft-versus-host disease is among the most common clinical complications following
allogeneic hematopoietic stem cell transplantation. It causes inflammation-mediated …

Topical neurokinin-1 receptor antagonist fosaprepitant ameliorates ocular graft-versus-host disease in a preclinical mouse model

RML Vitar, F Bonelli, A Atay, F Triani, P Fonteyne… - Experimental Eye …, 2021 - Elsevier
Purpose to assess the effect of topical administration of the Neurokin-1 receptor (NK1R)
antagonist Fosaprepitant in a pre-clinical model of ocular Graft-versus-Host disease …