Technologies for imaging the pathophysiology of Alzheimer disease (AD) now permit
studies of the relationships between the two major proteins deposited in this disease …

Brain aging is a complex process that affects everything from the subcellular to the organ
level, begins early in life, and accelerates with age. Morphologically, brain aging is primarily …

Alzheimer's disease (AD) is a slowly progressing disorder in which pathophysiological
abnormalities, detectable in vivo by biomarkers, precede overt clinical symptoms by many …

We directly assessed mesial temporal activity using intracranial foramen ovale electrodes in
two patients with Alzheimer's disease (AD) without a history or EEG evidence of seizures …

What can be expected in normal aging, and where does normal aging stop and pathological
neurodegeneration begin? With the slow progression of age-related dementias such as …

For more than 50 years, psychologists, gerontologists, and, more recently, neuroscientists
have considered the possibility of successful aging. How to define successful aging remains …

Blood–brain barrier (BBB) breakdown can disrupt nutrient supply and waste removal, which
affects neuronal functioning. Currently, dynamic contrast-enhanced (DCE) MRI is the …

Human cortical thickness and surface area are genetically independent, emerge through
different neurobiological events during development, and are sensitive to different clinical …

Importance Typical cognitive aging may be defined as age-associated changes in cognitive
performance in individuals who remain free of dementia. Ideally, the full adult age spectrum …

Higher order speeded cognitive abilities depend on efficient coordination of activity across
the brain, rendering them vulnerable to age reductions in structural and functional brain …