Targeting protein folding: a novel approach for the treatment of pathogenic bacteria
NJ Scheuplein, NM Bzdyl, EA Kibble… - Journal of Medicinal …, 2020 - ACS Publications
Infectious diseases are a major cause of morbidity and mortality worldwide, exacerbated by
increasing antibiotic resistance in many bacterial species. The development of drugs with …
increasing antibiotic resistance in many bacterial species. The development of drugs with …
Identification and optimization of PrsA in Bacillus subtilis for improved yield of amylase
A Quesada-Ganuza, M Antelo-Varela… - Microbial cell …, 2019 - Springer
Background PrsA is an extracytoplasmic folding catalyst essential in Bacillus subtilis.
Overexpression of the native PrsA from B. subtilis has repeatedly lead to increased amylase …
Overexpression of the native PrsA from B. subtilis has repeatedly lead to increased amylase …
Functional analysis of the glucan degradation locus in Caldicellulosiruptor bescii reveals essential roles of component glycoside hydrolases in plant biomass …
JM Conway, BS McKinley, NL Seals… - Applied and …, 2017 - Am Soc Microbiol
The ability to hydrolyze microcrystalline cellulose is an uncommon feature in the microbial
world, but it can be exploited for conversion of lignocellulosic feedstocks into biobased fuels …
world, but it can be exploited for conversion of lignocellulosic feedstocks into biobased fuels …
Antimicrobial resistance determinants are associated with Staphylococcus aureus bacteraemia and adaptation to the healthcare environment: a bacterial genome …
BC Young, CH Wu, J Charlesworth… - Microbial …, 2021 - microbiologyresearch.org
Staphylococcus aureus is a major bacterial pathogen in humans, and a dominant cause of
severe bloodstream infections. Globally, antimicrobial resistance (AMR) in S. aureus …
severe bloodstream infections. Globally, antimicrobial resistance (AMR) in S. aureus …
Microbial cyclophilins: specialized functions in virulence and beyond
M Dimou, A Venieraki, P Katinakis - World Journal of Microbiology and …, 2017 - Springer
Cyclophilins belong to the superfamily of peptidyl-prolyl cis/trans isomerases (PPIases, EC:
5.2. 1.8), the enzymes that catalyze the cis/trans isomerization of peptidyl-prolyl peptide …
5.2. 1.8), the enzymes that catalyze the cis/trans isomerization of peptidyl-prolyl peptide …
The small RNA Teg41 regulates expression of the alpha phenol-soluble modulins and is required for virulence in Staphylococcus aureus
Small RNAs (sRNAs) remain an understudied class of regulatory molecules in bacteria in
general and in Gram-positive bacteria in particular. In the major human pathogen …
general and in Gram-positive bacteria in particular. In the major human pathogen …
The phosphatase Bph and peptidyl-prolyl isomerase PrsA are required for gelatinase expression and activity in Enterococcus faecalis
JLE Willett, EB Robertson, GM Dunny - Journal of bacteriology, 2022 - Am Soc Microbiol
Enterococcus faecalis is a common commensal bacterium in the gastrointestinal tract as well
as a frequent nosocomial pathogen. The secreted metalloprotease gelatinase (GelE) is an …
as a frequent nosocomial pathogen. The secreted metalloprotease gelatinase (GelE) is an …
Flanking N- and C-terminal domains of PrsA in Streptococcus suis type 2 are crucial for inducing cell death independent of TLR2 recognition
X Jiang, G Yu, L Zhu, A Siddique, D Zhan, L Zhou… - Virulence, 2023 - Taylor & Francis
ABSTRACT Streptococcus suis type 2 (SS2), a major emerging/re-emerging zoonotic
pathogen found in humans and pigs, can cause severe clinical infections, and pose public …
pathogen found in humans and pigs, can cause severe clinical infections, and pose public …
Staphylococcus aureus responds to physiologically relevant temperature changes by altering its global transcript and protein profile
RA Bastock, EC Marino, RE Wiemels, DL Holzschu… - Msphere, 2021 - Am Soc Microbiol
Staphylococcus aureus is an opportunistic pathogen that colonizes the anterior nares of 30
to 50% of the population. Colonization is most often asymptomatic; however, self-inoculation …
to 50% of the population. Colonization is most often asymptomatic; however, self-inoculation …
Unique virulence role of post-translocational chaperone PrsA in shaping Streptococcus pyogenes secretome
ZY Wu, A Campeau, CH Liu, DJ Gonzalez… - Virulence, 2021 - Taylor & Francis
Streptococcus pyogenes (group A Streptococcus, GAS) is a strict human pathogen causing
a broad spectrum of diseases and a variety of autoimmune sequelae. The pathogenesis of …
a broad spectrum of diseases and a variety of autoimmune sequelae. The pathogenesis of …