Aurora kinases are serine/threonine kinases essential for the onset and progression of
mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit …

Aurora kinases, a family of serine/threonine kinases, consisting of Aurora A (AURKA),
Aurora B (AURKB) and Aurora C (AURKC), are essential kinases for cell division via …

Although targeted therapies often elicit profound initial patient responses, these effects are
transient due to residual disease leading to acquired resistance. How tumors transition …

The Aurora kinase family is comprised of three serine/threonine kinases, Aurora‐A, Aurora‐
B, and Aurora‐C. Among these, Aurora‐A and Aurora‐B play central roles in mitosis …

Abstract The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in
malignant transformation, prevention of apoptosis, drug resistance and metastasis. The …

Importance Aurora A kinase (AURKA) activation, related in part toAURKAamplification and
variants, is associated with downregulation of estrogen receptor (ER) α expression …

Centrosome-localized mitotic Aurora kinase A (AURKA) facilitates G2/M events. Here we
show that AURKA translocates to the nucleus and causes distinct oncogenic properties in …

Stem and progenitor cells are characterized by their ability to self-renew and produce
differentiated progeny. A fine balance between these processes is achieved through …

Faithful eucaryotic cell division requires spatio-temporal orchestration of multiple sequential
events. To ensure the dynamic nature of these molecular and morphological transitions, a …

Triple-negative breast cancer (TNBCs) account for 15–20% of all breast cancers and
represent the most aggressive subtype of this malignancy. Early tumor relapse and …