Crohn's disease and ulcerative colitis are idiopathic inflammatory bowel disorders. In this
paper, we discuss how environmental factors (eg, geography, cigarette smoking, sanitation …

Inflammatory bowel disease: Etiology and pathogenesis - ScienceDirect Skip to main contentSkip
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The gastrointestinal tract is coated by a thick layer of mucus that forms the front line of innate
host defense. Mucus consists of high molecular weight glycoproteins called mucins that are …

Crohn's disease, and ulcerative colitis, the two main types of chronic inflammatory bowel
disease, are multifactorial conditions of unknown aetiology. A susceptibility locus for Crohn's …

Crohn's disease is a chronic inflammatory disorder of the gastrointestinal tract, which is
thought to result from the effect of environmental factors in a genetically predisposed host. A …

In recent years the status of the inflammatory bowel diseases (IBDs) as canonical
autoimmune diseases has risen steadily with the recognition that these diseases are, at their …

The human gut relies on several cellular and molecular mechanisms to allow for an intact
and dynamical intestinal barrier. Normally, only small amounts of luminal content pass the …

The chronic inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis, are
recognized as important causes of gastrointestinal disease in children and adults. In this …

The first and still the only book of its kind, this volume offers a concise introduction to human
genetic linkage analysis and gene mapping. Jurg Ott provides mathematical and statistical …

The major histocompatibility complex (MHC) is one of the most extensively studied regions
in the human genome because of the association of variants at this locus with autoimmune …