The active transport of organelles and other cargos along the axon is required to maintain
neuronal health and function, but we are just beginning to understand the complex …

The growth and migration of neurons require continuous remodelling of the neuronal
cytoskeleton, providing a versatile cellular framework for force generation and guided …

Highlights•Growth cone formation requires a precise actin and microtubule organization.•
Modulating cytoskeleton stability affects growth cone formation and axon elongation.• …

Axon regeneration in the CNS is inhibited by many extrinsic and intrinsic factors. Because
these act in parallel, no single intervention has been sufficient to enable full regeneration of …

Among the variety of post-translational modifications to which microtubules are subjected,
the detyrosination/re-tyrosination cycle is specific to tubulin. It is conserved by evolution and …

Although neurons execute a cell intrinsic program of axonal growth during development,
following the establishment of connections, the developmental growth capacity declines …

La neuroplasticidad es la potencialidad del sistema nervioso de modificarse para formar
conexiones nerviosas en respuesta a la información nueva, la estimulación sensorial, el …

Microtubules (MTs) are an essential component of the neuronal cytoskeleton; they are
involved in various aspects of neuron development, maintenance, and functions including …

Kinesin motor proteins play a fundamental role for normal neuronal development by
controlling intracellular cargo transport and microtubule (MT) cytoskeleton organization …

The failure of axons to regenerate in the damaged mammalian CNS is the main impediment
to functional recovery. There are many molecules and structures in the environment of the …