The involvement of cellular senescence in the initiation and propagation of diseases is
clearly characterized, making the elimination of senescent cells essential to treat age-related …

Diabetes is associated with numerous comorbidities, one of which is increased vulnerability
to infections. This review will focus on how diabetes mellitus (DM) affects the immune system …

Background Type 1 diabetes mellitus (T1DM) is a prototypic endocrine autoimmune disease
resulting from an immune-mediated destruction of pancreatic insulin-secreting β cells. A …

Abstract Treatment of patients with recent-onset type 1 diabetes with an anti-CD3 antibody
leads to the transient stabilization of C-peptide levels in responder patients. Partial efficacy …

Background Around 10% of people with HIV (PWH) exhibit a low-level viremia (LLV) under
antiretroviral therapy (ART). However, its origin and clinical significance are largely …

Purpose Developmental abnormalities in B cells is one of the key players in autoimmune
diabetes, but little is known about its role in latent autoimmune diabetes in adults (LADA) …

Regulatory T cells (Tregs) are a specialized subgroup of T-cell lymphocytes that is crucial for
maintaining immune homeostasis and preventing excessive immune responses. Depending …

Autoimmune destruction of pancreatic β cells results in type 1 diabetes (T1D), with
pancreatic immune infiltrate representing a key feature in this process. Studies of human …

The adaptive immune system protects the body by remembering previously encountered
antigens, so it can react more efficiently when encountering the same antigen in the future …

Cellular senescence is a programmed state of cell cycle arrest that involves a complex
immunogenic secretome, eliciting immune surveillance and senescent cell clearance …