Yin Yang 1 (YY1), a dual function transcription factor, is known to regulate transcriptional
activation and repression of many genes associated with multiple cellular processes …

The identification and characterization of mammalian core promoters and transcription start
sites is a prerequisite to understanding how RNA polymerase II transcription is controlled …

Current catalogs of regulatory sequences in the human genome are still incomplete and lack
cell type resolution. To profile the activity of gene regulatory elements in diverse cell types …

The molecular mechanism underlying brain regeneration in vertebrates remains elusive. We
performed spatial enhanced resolution omics sequencing (Stereo-seq) to capture spatially …

Arabidopsis thaliana is a long established model species for plant molecular biology,
genetics and genomics, and studies of A. thaliana gene function provide the basis for …

In mammals, extensive chromatin reorganization is essential for reprogramming terminally
committed gametes to a totipotent state during preimplantation development. However, the …

Regulated transcription controls the diversity, developmental pathways and spatial
organization of the hundreds of cell types that make up a mammal. Using single-molecule …

Upon fertilization, drastic chromatin reorganization occurs during preimplantation
development. However, the global chromatin landscape and its molecular dynamics in this …

Although the similarities between humans and mice are typically highlighted,
morphologically and genetically, there are many differences. To better understand these two …

Sexual reproduction in flowering plants involves double fertilization, the union of two sperm
from pollen with two sex cells in the female embryo sac. Modern plant breeders increasingly …