Besides extracellular deposition of amyloid beta and formation of phosphorylated tau in the
brains of patients with Alzheimer's disease (AD), the pathogenesis of AD is also thought to …

Neurodegeneration is characterized by a disturbance in neurotransmitter-mediated
signaling pathways. Recent studies have highlighted the significant role of transition metal …

Beyond the well-explored proposition of protein aggregation or amyloidosis as the central
event in amyloidogenic diseases like Alzheimer's Disease (AD), and Type 2 Diabetes …

Conspectus Redox active iron is utilized in biology for various electron transfer and catalytic
reactions essential for life, yet this same chemistry mediates the formation of partially …

Amyloids are protein aggregates bearing a highly ordered cross β structural motif, which
may be functional but are mostly pathogenic. Their formation, deposition in tissues and …

A novel electrochemical sensor was constructed based on an enzyme-mediated
physiological reaction between neurotransmitter serotonin per-oxidation to reconstruct dual …

Alzheimer's disease (AD) is a multifaceted disease that is characterized by increased
oxidative stress, metal-ion dysregulation, and the formation of intracellular neurofibrillary …

Background & motivation Peptides and proteins can interact with heme through His, Tyr, or
Cys in heme-regulatory motifs (HRMs). The Cys-Pro dipeptide is a well investigated HRM …

The neuromodulator 5-hydroxytryptamine, known as serotonin, plays a key regulatory role in
the central nervous system and peripheral organs; however, several research revelations …

The amyloid cascade hypothesis attributes the neurodegeneration observed in Alzheimer's
disease (AD) to the deposition of the amyloid β (Aβ) peptide into plaques and fibrils in the …