Advantages and limitations of animal schizophrenia models

M Białoń, A Wąsik - International Journal of Molecular Sciences, 2022 - mdpi.com
Mental illness modeling is still a major challenge for scientists. Animal models of
schizophrenia are essential to gain a better understanding of the disease etiopathology and …

The role of IgLON cell adhesion molecules in neurodegenerative diseases

M Salluzzo, C Vianello, S Abdullatef, R Rimondini… - Genes, 2023 - mdpi.com
In the brain, cell adhesion molecules (CAMs) are critical for neurite outgrowth, axonal
fasciculation, neuronal survival and migration, and synapse formation and maintenance …

Altered expression profile of IgLON family of neural cell adhesion molecules in the dorsolateral prefrontal cortex of schizophrenic patients

K Karis, KL Eskla, M Kaare, K Täht, J Tuusov… - Frontiers in molecular …, 2018 - frontiersin.org
Neural adhesion proteins are crucial in the development and maintenance of functional
neural connectivity. Growing evidence suggests that the IgLON family of neural adhesion …

Neural cell adhesion molecule Negr1 deficiency in mouse results in structural brain endophenotypes and behavioral deviations related to psychiatric disorders

K Singh, M Jayaram, M Kaare, E Leidmaa… - Scientific reports, 2019 - nature.com
Abstract Neuronal growth regulator 1 (NEGR1) belongs to the immunoglobulin (IgLON)
superfamily of cell adhesion molecules involved in cortical layering. Recent functional and …

Depression-Associated Negr1 Gene-Deficiency Induces Alterations in the Monoaminergic Neurotransmission Enhancing Time-Dependent Sensitization to …

M Kaare, M Jayaram, T Jagomäe, K Singh, K Kilk… - Brain Sciences, 2022 - mdpi.com
In GWAS studies, the neural adhesion molecule encoding the neuronal growth regulator 1
(NEGR1) gene has been consistently linked with both depression and obesity. Although the …

[HTML][HTML] Schizophrenia, a disease of impaired dynamic metabolic flexibility: A new mechanistic framework

Z Sarnyai, D Ben-Shachar - Psychiatry Research, 2024 - Elsevier
Schizophrenia is a chronic, neurodevelopmental disorder with unknown aetiology and
pathophysiology that emphasises the role of neurotransmitter imbalance and abnormalities …

Expression and impact of Lsamp neural adhesion molecule in the serotonergic neurotransmission system

A Bregin, M Kaare, T Jagomäe, K Karis, K Singh… - Pharmacology …, 2020 - Elsevier
Limbic system associated membrane protein (Lsamp) is a neural adhesion protein which
has been recently found to be differentially expressed between serotonergic neuron …

Enhanced molecular appreciation of psychiatric disorders through high-dimensionality data acquisition and analytics

J van Gastel, JO Hendrickx, H Leysen, B Martin… - … Disorders: Methods and …, 2019 - Springer
The initial diagnosis, molecular investigation, treatment, and posttreatment care of major
psychiatric disorders (schizophrenia and bipolar depression) are all still significantly …

Evaluation of molecular brain changes associated with environmental stress in rodent models compared to human major depressive disorder: A proteomic systems …

DA Cox, MG Gottschalk, V Stelzhammer… - The World Journal of …, 2018 - Taylor & Francis
Objectives: Rodent models of major depressive disorder (MDD) are indispensable when
screening for novel treatments, but assessing their translational relevance with human brain …

Proteomic Characteristics of the Prefrontal Cortex and Hippocampus in Mice with Chronic Ketamine-Induced Anxiety and Cognitive Impairment

L Xiao, Y Wei, H Yang, W Fan, L Jiang, Y Ye, Y Qin… - Neuroscience, 2024 - Elsevier
Schizophrenia, a complex psychiatric disorder with diverse symptoms, has been linked to
ketamine, known for its N-methyl-D-aspartate (NMDA) receptor antagonistic properties …