Pipeline of anti‐Mycobacterium abscessus small molecules: Repurposable drugs and promising novel chemical entities

A Egorova, M Jackson, V Gavrilyuk… - Medicinal research …, 2021 - Wiley Online Library
The Mycobacterium abscessus complex is a group of emerging pathogens that are difficult
to treat. There are no effective drugs for successful M. abscessus pulmonary infection …

Quinoline derivatives volunteering against antimicrobial resistance: rational approaches, design strategies, structure activity relationship and mechanistic insights

N Kumar, A Khanna, K Kaur, H Kaur, A Sharma… - Molecular Diversity, 2023 - Springer
Emergence of antimicrobial resistance has become a great threat to human species as there
is shortage of development of new antimicrobial agents. So, its mandatary to combat AMR …

Identification of active molecules against Mycobacterium tuberculosis through machine learning

Q Ye, X Chai, D Jiang, L Yang, C Shen… - Briefings in …, 2021 - academic.oup.com
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb) and
it has been one of the top 10 causes of death globally. Drug-resistant tuberculosis (XDR-TB) …

Design, synthesis, and evaluation of new 2-(quinoline-4-yloxy) acetamide-based antituberculosis agents

AF Borsoi, JD Paz, BL Abbadi, FS Macchi… - European Journal of …, 2020 - Elsevier
Using a classical molecular simplification approach, a series of 36 quinolines were
synthesized and evaluated as in vitro inhibitors of Mycobacterium tuberculosis (M …

Current insights into the chemistry and antitubercular potential of benzimidazole and imidazole derivatives

D Parwani, S Bhattacharya, A Rathore… - Mini Reviews in …, 2021 - ingentaconnect.com
Tuberculosis is a disease caused by Mycobacterium tuberculosis (Mtb), affecting millions of
people worldwide. The emergence of drug resistance is a major problem in the successful …

Contribution of N‐heterocycles towards anti‐tubercular drug discovery (2014–2019); predicted and reengineered molecular frameworks

D Atukuri, R Gunjal, N Holagundi… - Drug Development …, 2021 - Wiley Online Library
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, responsible
for high death frequency every year all over the world. In this regard, efficient drug‐design …

Synthetic studies towards isomeric pyrazolopyrimidines as potential ATP synthesis inhibitors of Mycobacterium tuberculosis. Structural correction of reported N-(6-(2 …

PJ Choi, GL Lu, HS Sutherland, AC Giddens… - Tetrahedron …, 2022 - Elsevier
During our studies into preparing analogues of pyrazolopyrimidine as ATP synthesis
inhibitors of Mycobacterium tuberculosis, a regiospecific condensation reaction between …

[HTML][HTML] Influence of 3-nitropropionic acid on physiological and behavioral responses in zebrafish larvae and adults

MT Wiprich, R Zanandrea, S Altenhofen… - … and Physiology Part C …, 2020 - Elsevier
Long-term treatment with 3-nitropropionic acid (3-NPA), a toxin derived from plants and
fungi, may reproduce symptoms and biochemical characteristics of Huntington's disease …

Identification of potential inhibitors of Mycobacterium tuberculosis shikimate kinase: molecular docking, in silico toxicity and in vitro experiments

T Freitas de Freitas, CD Roth, BL Abbadi… - Journal of Computer …, 2023 - Springer
Tuberculosis (TB) is one of the main causes of death from a single pathological agent,
Mycobacterium tuberculosis (Mtb). In addition, the emergence of drug-resistant TB strains …

DBU-Promoted Deaminative Thiolation of 1H-Benzo[d]imidazol-2-amines and Benzo[d]oxazol-2-amines

L Zheng, W Mei, X Zou, Y Zhong, Y Wu… - The Journal of …, 2022 - ACS Publications
A facile and efficient catalyst-/metal-/oxidant-free DBU-promoted deaminative thiolation
reaction of 1 H-benzo [d] imidazol-2-amines and benzo [d] oxazol-2-amines has been …