Molecular mechanism of arsenic-induced neurotoxicity including neuronal dysfunctions

M Thakur, M Rachamalla, S Niyogi… - International Journal of …, 2021 - mdpi.com
Arsenic is a key environmental toxicant having significant impacts on human health. Millions
of people in developing countries such as Bangladesh, Mexico, Taiwan, and India are …

[HTML][HTML] Understanding arsenic toxicity: Implications for environmental exposure and human health

A Garkal, L Sarode, P Bangar, T Mehta… - Journal of Hazardous …, 2024 - Elsevier
Arsenic is a trace element and a metalloid which is prominently known as an environmental
hazard. At present, rising health apprehensions are linked to emanating from a wide array of …

[HTML][HTML] The developmental neurotoxicity of arsenic: cognitive and behavioral consequences of early life exposure

M Tolins, M Ruchirawat, P Landrigan - Annals of global health, 2014 - Elsevier
Background More than 200 million people worldwide are chronically exposed to arsenic.
Arsenic is a known human carcinogen, and its carcinogenic and systemic toxicity have been …

Mitochondrial oxidative stress and dysfunction in arsenic neurotoxicity: A review

C Prakash, M Soni, V Kumar - Journal of Applied Toxicology, 2016 - Wiley Online Library
Arsenic is a toxic metalloid present ubiquitously on earth. Since the last decade, it has
gained considerable attention due to its severe neurotoxic effects. Arsenic can cross the …

[HTML][HTML] The role of thymoquinone as a potent antioxidant in ameliorating the neurotoxic effect of sodium arsenate in female rat

RB Kassab, RE El-Hennamy - Egyptian Journal of Basic and Applied …, 2017 - Elsevier
Arsenic is a neurotoxic substance that makes the brain susceptible to free radicals.
Thymoquinone (TQ) is a potent antioxidant extracted from Nigella sativa seeds. It scavenges …

[图书][B] Critical aspects of EPA's IRIS assessment of inorganic arsenic: interim report

National Research Council, Life Studies… - 2013 - books.google.com
The US Environmental Protection Agency (EPA) Integrated Risk Information System (IRIS)
program develops toxicologic assessments of environmental contaminants. IRIS …

Identification of novel NRF2-dependent genes as regulators of lead and arsenic toxicity in neural progenitor cells

HR Park, D Azzara, ED Cohen, SR Boomhower… - Journal of Hazardous …, 2024 - Elsevier
Abstract Lead (Pb) and arsenic (As) are prevalent metal contaminants in the environment.
Exposures to these metals are associated with impaired neuronal functions and adverse …

Toxicity of two classes of arsenolipids and their water-soluble metabolites in human differentiated neurons

B Witt, S Meyer, F Ebert, KA Francesconi… - Archives of …, 2017 - Springer
Arsenolipids are lipid-soluble organoarsenic compounds, mainly occurring in marine
organisms, with arsenic-containing hydrocarbons (AsHCs) and arsenic-containing fatty …

Molecular mechanisms of environmental metal neurotoxicity: a focus on the interactions of metals with synapse structure and function

A Carmona, S Roudeau, R Ortega - Toxics, 2021 - mdpi.com
Environmental exposure to neurotoxic metals and metalloids such as arsenic, cadmium,
lead, mercury, or manganese is a global health concern affecting millions of people …

From the cover: arsenic induces hippocampal neuronal apoptosis and cognitive impairments via an up-regulated BMP2/Smad-dependent reduced BDNF/TrkB …

R Pandey, V Rai, J Mishra, K Mandrah… - Toxicological …, 2017 - academic.oup.com
Arsenic promotes hippocampal neuronal damage inducing cognitive impairments. However,
mechanism arbitrating arsenic-mediated cognitive deficits remains less-known. Here, we …