What are white matter hyperintensities made of? Relevance to vascular cognitive impairment

JM Wardlaw, MC Valdés Hernández… - Journal of the …, 2015 - Am Heart Assoc
White matter hyperintensities (WMH) of presumed vascular origin, also referred to as
leukoaraiosis, are a very common finding on brain magnetic resonance imaging (MRI) or …

The pathology and pathophysiology of vascular dementia

RN Kalaria - Neuropharmacology, 2018 - Elsevier
Vascular dementia (VaD) is widely recognised as the second most common type of
dementia. Consensus and accurate diagnosis of clinically suspected VaD relies on wide …

[HTML][HTML] Emerging concepts in vascular dementia: a review

SC Bir, MW Khan, V Javalkar, EG Toledo… - Journal of Stroke and …, 2021 - Elsevier
Abstract Objective Vascular dementia (VaD) is the second most common cause of dementia
and a major health concern worldwide. A comprehensive review on VaD is warranted for …

The overlap between vascular disease and Alzheimer's disease-lessons from pathology

J Attems, KA Jellinger - BMC medicine, 2014 - Springer
Recent epidemiological and clinico-pathological data indicate considerable overlap
between cerebrovascular disease (CVD) and Alzheimer's disease (AD) and suggest …

Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging

JM Wardlaw, C Smith, M Dichgans - The Lancet Neurology, 2013 - thelancet.com
The term cerebral small vessel disease (SVD) describes a range of neuroimaging,
pathological, and associated clinical features. Clinical features range from none, to discrete …

Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer's disease

RN Kalaria - Acta neuropathologica, 2016 - Springer
Vascular dementia (VaD) is recognised as a neurocognitive disorder, which is explained by
numerous vascular causes in the general absence of other pathologies. The heterogeneity …

Relationships of dietary patterns, foods, and micro-and macronutrients with Alzheimer's disease and late-life cognitive disorders: a systematic review

V Solfrizzi, C Custodero, M Lozupone… - Journal of …, 2017 - content.iospress.com
In the last decade, the association between diet and cognitive function or dementia has
been largely investigated. In the present article, we systematically reviewed observational …

Brain arteriolosclerosis

BL Blevins, HV Vinters, S Love, DM Wilcock… - Acta …, 2021 - Springer
Abstract Brain arteriolosclerosis (B-ASC), characterized by pathologic arteriolar wall
thickening, is a common finding at autopsy in aged persons and is associated with cognitive …

Cerebral small vessel disease, hypertension, and vascular contributions to cognitive impairment and dementia

AH Hainsworth, HS Markus, JA Schneider - Hypertension, 2024 - Am Heart Assoc
Hypertension-associated cerebral small vessel disease is a common finding in older people.
Strongly associated with age and hypertension, small vessel disease is found at autopsy in …

[HTML][HTML] Blood-brain barrier failure as a core mechanism in cerebral small vessel disease and dementia: evidence from a cohort study

JM Wardlaw, SJ Makin, MCV Hernández… - Alzheimer's & …, 2017 - Elsevier
Introduction Small vessel disease (SVD) is a common contributor to dementia. Subtle blood-
brain barrier (BBB) leakage may be important in SVD-induced brain damage. Methods We …