High level extracellular production of recombinant human interferon alpha 2b in glycoengineered Pichia pastoris: culture medium optimization, high cell density …

S Katla, B Karmakar, SRR Tadi, N Mohan… - Journal of applied …, 2019 - academic.oup.com
Aims The present study was aimed at design of experiments (DoE)‐and artificial intelligence‐
based culture medium optimization for high level extracellular production of a novel …

Control of specific growth rate for the enhanced production of human interferon α2b in glycoengineered Pichia pastoris: process analytical technology guided …

S Katla, N Mohan, SS Pavan, U Pal… - Journal of Chemical …, 2019 - Wiley Online Library
BACKGROUND Process variability in bioprocess systems involving genetically engineered
strains is a common bottleneck and a real‐time insight of the on‐going process is crucial to …

Antioxidant and cytotoxic activities of lactic acid bacteria on colorectal cancer WiDr cell line

PH Wisnuwardhani, RA Ningrum… - … Journal of Cancer …, 2021 - ijcc.chemoprev.org
Colorectal cancer (CRC) is one of the leading causes of cancer and cancer-related deaths
worldwide. Lactic acid bacteria (LAB) are bacteria that have potential activity as an inhibitor …

[PDF][PDF] Human interferon Alpha2a as anti Hepatitis B and C

RA Ningrum - Indonesian Journal of Clinical …, 2017 - download.garuda.kemdikbud.go.id
Hepatitis is an inflammation of the liver mainly caused by hepatitis viruses. There are 5
different types of hepatitis based on the infecting virus; A, B, C, D and E. Hepatitis B and C …

[PDF][PDF] Expression of No Affinity Tagged Recombinant Human Interferon Alpha-2a in Methilotropic Yeast Pichia pastoris

N Herawati, A Wardiana, RA Ningrum - Annalese Bogorienses, 2015 - academia.edu
Recombinant human interferon alpha-2a (rhIFNα-2a) has been widely used for clinical
therapy as antiviral, anticancer as well as immunomodulator. In this study, the open reading …

[PDF][PDF] Stability of recombinant human interferon alpha-2b produced in methylotropic yeast Pichia pastoris

S Wathon, S Budiarti, HP Wisnuwardhani… - Int J Res Pharm …, 2015 - researchgate.net
The stability of recombinant human interferon alpha-2b (rhIFNα-2b) remains a great
challenge for Pharmaceutical science. In previous research we constructed open reading …

Interferon: Role in health, current trends and therapeutic potentials

IK Uchendu, NP Ojiako - Journal of Drug Delivery and Therapeutics, 2020 - jddtonline.info
This mini review presents the current trends and topical issues on interferon. This article
illustrates the theoretical background and details about interferon, its mechanism of action or …

[PDF][PDF] Heterologous Expression of Interferon α-2b in Lactococcus lactis and its Biological Activity against Colorectal Cancer Cells

L Meilina, S Budiarti, AZ Mustopa… - Microbiology and …, 2021 - vivantechnologies.com
Type I Interferons (IFNα) are known for their role as biological anticancer agents owing to
their cell-apoptosis inducing properties. Development of an appropriate, cost-effective host …

[PDF][PDF] Inhibitory Activity of Endophytic Fungi Isolated from Sukabumi Turmeric Plant (Curcuma longa L.) towards MCF-7 Cell Line

RA Ningrum, PHW Bustanussalam… - Indonesian Journal of …, 2017 - academia.edu
Kunyit or turmeric plant (Curcuma longa L.) is a native southern Asia plant that has been
widely used as herbal medicine. In our previous research, we isolated and screened 44 of …

[PDF][PDF] Antioxidant and Cytotoxic Activities of Lactic Acid Bacteria on Colorectal Cancer WiDr Cell Line

AZ Mustopa - researchgate.net
Colorectal cancer (CRC) is one of the leading causes of cancer and cancer-related deaths
worldwide. Lactic acid bacteria (LAB) are bacteria that have potential activity as an inhibitor …