Inert and stable radiolabeling of monoclonal antibodies (mAb), antibody fragments, or
antibody mimetics with radiometals is a prerequisite for immuno-PET. While radiolabeling is …

Immuno-positron emission tomography (immunoPET) is a molecular imaging modality
combining the high sensitivity of PET with the specific targeting ability of monoclonal …

Purpose Multiple myeloma (MM) remains incurable and its diagnosis relies heavily on bone
marrow aspiration and biopsy. CD38 is a glycoprotein highly specific for MM. Antibody …

Claudin 18.2 (CLDN18. 2) is an emerging target for the treatment of gastric cancers. We aim
to develop tracers to image the expression of CLDN18. 2. A humanized nanobody targeting …

Background Although immunotherapy has revolutionized treatment strategies for some
types of cancers, most patients failed to respond or obtain long-term benefit. Tumor …

Compelling evidence indicates that radiotherapy (RT) has a systemic inhibitory effect on
nonirradiated lesions (abscopal effect) in addition to the ablation of irradiated tumors …

Abstract Claudin 18.2 (CLDN18. 2) is an emerging target for the treatment of CLDN18. 2-
expressing cancers such as gastric and pancreatic cancers. Cell and antibody therapies …

Noninvasive diagnosis of multiple myeloma (MM) is a clinical challenge. CD38 is an
established biomarker for MM, and the development of CD38-targeted radiotracers may …

Radiopharmaceuticals play a critical role in nuclear medicine, providing novel tools for
specifically delivering radioisotopes for the diagnosis and treatment of cancers. As the …

Purpose We dual-labeled an intercellular adhesion molecule-1 (ICAM-1) monoclonal
antibody (mAb) and evaluated its effectiveness for lesion detection and surgical navigation …