APT‐weighted MRI: techniques, current neuro applications, and challenging issues

J Zhou, HY Heo, L Knutsson… - Journal of Magnetic …, 2019 - Wiley Online Library
Amide proton transfer‐weighted (APTw) imaging is a molecular MRI technique that
generates image contrast based predominantly on the amide protons in mobile cellular …

Magnetization transfer contrast and chemical exchange saturation transfer MRI. Features and analysis of the field-dependent saturation spectrum

PCM Van Zijl, WW Lam, J Xu, L Knutsson, GJ Stanisz - Neuroimage, 2018 - Elsevier
Abstract Magnetization Transfer Contrast (MTC) and Chemical Exchange Saturation
Transfer (CEST) experiments measure the transfer of magnetization from molecular protons …

An overview of CEST MRI for non-MR physicists

B Wu, G Warnock, M Zaiss, C Lin, M Chen, Z Zhou… - EJNMMI physics, 2016 - Springer
The search for novel image contrasts has been a major driving force in the magnetic
resonance (MR) research community, in order to gain further information on the body's …

Chemical exchange saturation transfer (CEST) and MR Z-spectroscopy in vivo: a review of theoretical approaches and methods

M Zaiss, P Bachert - Physics in Medicine & Biology, 2013 - iopscience.iop.org
Chemical exchange saturation transfer (CEST) of metabolite protons that undergo exchange
processes with the abundant water pool enables a specific contrast for magnetic resonance …

Inverse Z‐spectrum analysis for spillover‐, MT‐, and T1‐corrected steady‐state pulsed CEST‐MRI – application to pH‐weighted MRI of acute stroke

M Zaiss, J Xu, S Goerke, IS Khan, RJ Singer… - NMR in …, 2014 - Wiley Online Library
Endogenous chemical exchange saturation transfer (CEST) effects are always diluted by
competing effects, such as direct water proton saturation (spillover) and semi‐solid …

CEST signal at 2 ppm (CEST@2ppm) from Z‐spectral fitting correlates with creatine distribution in brain tumor

K Cai, A Singh, H Poptani, W Li, S Yang… - NMR in …, 2015 - Wiley Online Library
In general, multiple components such as water direct saturation, magnetization transfer (MT),
chemical exchange saturation transfer (CEST) and aliphatic nuclear Overhauser effect …

Assessing skeletal muscle mass: historical overview and state of the art

SB Heymsfield, M Adamek, MC Gonzalez, G Jia… - Journal of cachexia …, 2014 - Springer
Background Even though skeletal muscle (SM) is the largest body compartment in most
adults and a key phenotypic marker of sarcopenia and cachexia, SM mass was until recently …

A technique for in vivo mapping of myocardial creatine kinase metabolism

M Haris, A Singh, K Cai, F Kogan, J McGarvey… - Nature medicine, 2014 - nature.com
ATP derived from the conversion of phosphocreatine to creatine by creatine kinase provides
an essential chemical energy source that governs myocardial contraction. Here, we …

Imaging the physiological evolution of the ischemic penumbra in acute ischemic stroke

R Leigh, L Knutsson, J Zhou… - Journal of Cerebral …, 2018 - journals.sagepub.com
We review the hemodynamic, metabolic and cellular parameters affected during early
ischemia and their changes as a function of approximate cerebral blood flow (CBF) …

In vivo imaging of phosphocreatine with artificial neural networks

L Chen, M Schär, KWY Chan, J Huang, Z Wei… - Nature …, 2020 - nature.com
Phosphocreatine (PCr) plays a vital role in neuron and myocyte energy homeostasis.
Currently, there are no routine diagnostic tests to noninvasively map PCr distribution with …