Role of NEK2 in tumorigenesis and tumor progression
J Xia, H Zhao, JL Edmondson, B Koss… - Trends in Molecular …, 2024 - cell.com
Never in mitosis A (NIMA)-related kinase 2 (NEK2) is a serine/threonine kinase found in the
nucleus and cytoplasm throughout the cell cycle. NEK2 is overexpressed in many cancers …
nucleus and cytoplasm throughout the cell cycle. NEK2 is overexpressed in many cancers …
High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma
Multiple myeloma (MM) growth is supported by an immune-tolerant bone marrow
microenvironment. Here, we find that loss of Never in mitosis gene A (NIMA)-related kinase …
microenvironment. Here, we find that loss of Never in mitosis gene A (NIMA)-related kinase …
Involvement of NEK2 and NEK9 in LPS-induced endothelial barrier dysfunction
N Barabutis, MS Akhter - Microvascular Research, 2024 - Elsevier
Endothelial hyperpermeability is the hallmark of severe lung injury, including acute
respiratory distress syndrome. Despite the fact that Never In Mitosis A (NIMA)-related kinase …
respiratory distress syndrome. Despite the fact that Never In Mitosis A (NIMA)-related kinase …
Antimalarial Drug Discovery from Natural and Synthetic Sources
NNSFNM Azam, S Othman… - Current Medicinal …, 2025 - benthamdirect.com
Malaria remains a significant global health threat despite extensive efforts aimed at its
eradication. Numerous challenges persist in eliminating the disease, chief among them …
eradication. Numerous challenges persist in eliminating the disease, chief among them …
Breaking barriers: NEK2 inhibition shines in multiple myeloma treatment
C Lischer, H Bruns - Cell Reports Medicine, 2023 - cell.com
Breaking barriers: NEK2 inhibition shines in multiple myeloma treatment Page 1 Preview
Breaking barriers: NEK2 inhibition shines in multiple myeloma treatment Christopher Lischer1,2,3 …
Breaking barriers: NEK2 inhibition shines in multiple myeloma treatment Christopher Lischer1,2,3 …
Evaluating the expression and prognostic value of genes encoding microtubule-associated proteins in lung cancer
N Singharajkomron, V Yodsurang, S Seephan… - International Journal of …, 2022 - mdpi.com
Microtubule-associated proteins (MAPs) play essential roles in cancer development. This
study aimed to identify transcriptomic biomarkers among MAP genes for the diagnosis and …
study aimed to identify transcriptomic biomarkers among MAP genes for the diagnosis and …
NEK2 plays an essential role in porcine embryonic development by maintaining mitotic division and DNA damage response via the Wnt/β‐catenin signalling pathway
SB Jeon, PS Jeong, HG Kang, MJ Kim, JH Yun… - Cell …, 2024 - Wiley Online Library
Abstract NIMA‐related kinase 2 (NEK2) is a serine/threonine protein kinase that regulates
mitosis and plays pivotal roles in cell cycle regulation and DNA damage repair. However, its …
mitosis and plays pivotal roles in cell cycle regulation and DNA damage repair. However, its …
Circular forms of dedicator of cytokinesis 1 promotes breast cancer progression by derepressing never in mitosis related kinase 2 via sponging miR‐128‐3p.
Z Ni, W Liu, G Pan, A Mao, J Liu… - Environmental …, 2023 - search.ebscohost.com
The conjecture of breast cancer is uncertain because of its explosive growth and the
complicated molecular mechanisms. Circular RNAs (circRNAs) are regulatory RNA …
complicated molecular mechanisms. Circular RNAs (circRNAs) are regulatory RNA …
[HTML][HTML] NEK2 promotes colorectal cancer progression by activating the TGF-β/Smad2 signaling pathway
H Qin, M Yuan, Y Yuan, F Xia, Y Yang - Translational Oncology, 2025 - Elsevier
Colorectal cancer (CRC) is a prevalent malignancy with poor patient survival, and NIMA-
associated kinase 2 (NEK2) has been implicated in the pathogenesis and progression of …
associated kinase 2 (NEK2) has been implicated in the pathogenesis and progression of …
[HTML][HTML] Construction and validation of a mutation-related model in papillary renal cell carcinoma and associated immune infiltration
X Li, Y Liu, L Zhou, J Wang, X Yang - Kidney and Blood Pressure …, 2024 - karger.com
Background: To improve the clinical evaluation of the prognosis of papillary renal cell
carcinoma (PRCC), we screened a model to predict the survival of patients with mutations in …
carcinoma (PRCC), we screened a model to predict the survival of patients with mutations in …