Dietary and physiological effects of zinc on the immune system

I Wessels, HJ Fischer, L Rink - Annual review of nutrition, 2021 - annualreviews.org
Evidence for the importance of zinc for all immune cells and for mounting an efficient and
balanced immune response to various environmental stressors has been accumulating in …

The redox biology of redox-inert zinc ions

W Maret - Free Radical Biology and Medicine, 2019 - Elsevier
Zinc (II) ions are redox-inert in biology. Yet, their interaction with sulfur of cysteine in cellular
proteins can confer ligand-centered redox activity on zinc coordination sites, control protein …

Simultaneous Zn2+ tracking in multiple organelles using super-resolution morphology-correlated organelle identification in living cells

H Fang, S Geng, M Hao, Q Chen, M Liu, C Liu… - Nature …, 2021 - nature.com
Zn2+ plays important roles in metabolism and signaling regulation. Subcellular Zn2+
compartmentalization is essential for organelle functions and cell biology, but there is …

Role of zinc in female reproduction

TB Garner, JM Hester, A Carothers… - Biology of …, 2021 - academic.oup.com
Zinc is a critical component in a number of conserved processes that regulate female germ
cell growth, fertility, and pregnancy. During follicle development, a sufficient intracellular …

Zinc reduces hepatic lipid deposition and activates lipophagy via Zn2+/MTF‐1/PPARα and Ca2+/CaMKKβ/AMPK pathways

CC Wei, Z Luo, C Hogstrand, YH Xu, LX Wu… - The FASEB …, 2018 - Wiley Online Library
Zinc (Zn) deficiency is the most consistently discovered nutritional manifestations of fatty liver
disease. Although Zn is known to stimulate hepatic lipid oxidation, little is known about its …

Zinc enhances intestinal epithelial barrier function through the PI3K/AKT/mTOR signaling pathway in Caco-2 cells

Y Shao, PG Wolf, S Guo, Y Guo, HR Gaskins… - The Journal of …, 2017 - Elsevier
Zinc plays an important role in maintaining intestinal barrier function as well as modulating
cellular signaling recognition and protein kinase activities. The phosphatidylinositol 3-kinase …

[HTML][HTML] The obesity-autophagy-cancer axis: Mechanistic insights and therapeutic perspectives

AB Behrooz, M Cordani, A Fiore, M Donadelli… - Seminars in Cancer …, 2024 - Elsevier
Autophagy, a self-degradative process vital for cellular homeostasis, plays a significant role
in adipose tissue metabolism and tumorigenesis. This review aims to elucidate the complex …

Lysosomal dysfunction in proteinopathic neurodegenerative disorders: possible therapeutic roles of cAMP and zinc

JY Koh, HN Kim, JJ Hwang, YH Kim, SE Park - Molecular Brain, 2019 - Springer
A number of neurodegenerative diseases, including Alzheimer's disease, Parkinson's
disease, and amyotrophic lateral sclerosis, share intra-and/or extracellular deposition of …

Targeting autophagy to counteract obesity-associated oxidative stress

F Pietrocola, JM Bravo-San Pedro - Antioxidants, 2021 - mdpi.com
Reactive oxygen species (ROS) operate as key regulators of cellular homeostasis within a
physiological range of concentrations, yet they turn into cytotoxic entities when their levels …

[HTML][HTML] Zinc at the crossroads of exercise and proteostasis

JD Hernández-Camacho, C Vicente-García… - Redox biology, 2020 - Elsevier
Zinc is an essential element for all forms of life, and one in every ten human proteins is a
zinc protein. Zinc has catalytic, structural and signalling functions and its correct …