Calcium signaling and genetic rare diseases: An auditory perspective
EM Richard, T Maurice, B Delprat - Cell Calcium, 2023 - Elsevier
Deafness is a highly heterogeneous disorder which stems, for 50%, from genetic origins.
Sensory transduction relies mainly on sensory hair cells of the cochlea, in the inner ear …
Sensory transduction relies mainly on sensory hair cells of the cochlea, in the inner ear …
Oncomodulin regulates spontaneous calcium signalling and maturation of afferent innervation in cochlear outer hair cells
Cochlear outer hair cells (OHCs) are responsible for the exquisite frequency selectivity and
sensitivity of mammalian hearing. During development, the maturation of OHC afferent …
sensitivity of mammalian hearing. During development, the maturation of OHC afferent …
Absence of oncomodulin increases susceptibility to noise-induced outer hair cell death and alters mitochondrial morphology
KE Murtha, WD Sese, K Sleiman, J Halpage… - Frontiers in …, 2024 - frontiersin.org
Cochlear outer hair cells (OHCs) play a fundamental role in the hearing sensitivity and
frequency selectivity of mammalian hearing and are especially vulnerable to noise-induced …
frequency selectivity of mammalian hearing and are especially vulnerable to noise-induced …
[HTML][HTML] Two new mouse alleles of Ocm and Slc26a5
M Lachgar-Ruiz, NJ Ingham, E Martelletti, J Chen… - Hearing Research, 2024 - Elsevier
The genes Ocm (encoding oncomodulin) and Slc26a5 (encoding prestin) are expressed
strongly in outer hair cells and both are involved in deafness in mice. However, it is not clear …
strongly in outer hair cells and both are involved in deafness in mice. However, it is not clear …
Lack of Oncomodulin Increases ATP-Dependent Calcium Signaling and Susceptibility to Noise in Adult Mice
Tight regulation of Ca2+ is crucial for the function of cochlear outer hair cells (OHCs).
Dysregulation of Ca2+ homeostasis in OHCs is associated with impaired hearing function …
Dysregulation of Ca2+ homeostasis in OHCs is associated with impaired hearing function …
Early Sensory Deficits in Alzheimer's Disease: A Review of Potential Integrating Diagnostic Methods
Y Yang - Journal of Clinical and Translational Science - cambridge.org
Alzheimer's Disease (AD) is the most common cause of dementia globally, leading to
memory loss and cognitive decline. Accumulating studies have uncovered the correlation …
memory loss and cognitive decline. Accumulating studies have uncovered the correlation …
[引用][C] Effect of Oncomodulin on Afferent Inner Hair Cell and Efferent Outer Hair Cell Synaptopathy
P Thompson - 2022
[引用][C] Dysfunction of Calcium Regulation Mediates Processes Involved in Age-Related Hearing Loss
J Charles - 2022
[引用][C] Examining the Relationship between Alpha-Parvalbumin and Oncomodulin: A Pilot Study on the Calcium-Binding Proteins of the Inner Ear
A Le - 2022