Iron is a critical component of many cellular functions including DNA replication and repair,
and it is essential for cell vitality. As an essential element, iron is critical for maintaining …

The discovery of the iron-regulatory hormone hepcidin in 2001 has revolutionized our
understanding of iron disorders, and its measurement should advance diagnosis/treatment …

Iron overload causes progressive organ damage and is associated with arthritis, liver
damage, and heart failure. Elevated iron levels are present in 1%–5% of individuals; …

Recovery from blood loss requires a greatly enhanced supply of iron to support expanded
erythropoiesis. After hemorrhage, suppression of the iron-regulatory hormone hepcidin …

The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the
major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron …

Nuclear receptor coactivator 4 mediated ferritinophagy is an autophagic phenomenon that
specifically involves ferritin to release intracellular free iron. Ferritinophagy is implicated in …

Despite fluctuations in dietary iron intake and intermittent losses through bleeding, the
plasma iron concentrations in humans remain stable at 10–30μM. While most of the iron …

Under evolutionary pressure to counter the toxicity of iron and to maintain adequate iron
supply for hemoglobin synthesis and essential metabolic functions, humans and other …

Iron is vital for almost all organisms because of its ability to donate and accept electrons with
relative ease. It serves as a cofactor for many proteins and enzymes necessary for oxygen …

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