Formation and integration of new neurons in the adult hippocampus

A Denoth-Lippuner, S Jessberger - Nature Reviews Neuroscience, 2021 - nature.com
Neural stem cells (NSCs) generate new neurons throughout life in the mammalian brain.
Adult-born neurons shape brain function, and endogenous NSCs could potentially be …

The effects of microglia‐and astrocyte‐derived factors on neurogenesis in health and disease

T Araki, Y Ikegaya, R Koyama - European Journal of …, 2021 - Wiley Online Library
Hippocampal neurogenesis continues throughout life and has been suggested to play an
essential role in maintaining spatial cognitive function under physiological conditions. An …

Molecular landscapes of human hippocampal immature neurons across lifespan

Y Zhou, Y Su, S Li, BC Kennedy, DY Zhang, AM Bond… - Nature, 2022 - nature.com
Immature dentate granule cells (imGCs) arising from adult hippocampal neurogenesis
contribute to plasticity and unique brain functions in rodents, and are dysregulated in …

Adult-born dentate granule cells promote hippocampal population sparsity

SB McHugh, V Lopes-dos-Santos, GP Gava… - Nature …, 2022 - nature.com
The dentate gyrus (DG) gates neocortical information flow to the hippocampus. Intriguingly,
the DG also produces adult-born dentate granule cells (abDGCs) throughout the lifespan …

Single-cell RNA sequencing uncovers a neuron-like macrophage subset associated with cancer pain

PCT Tang, JYF Chung, J Liao, MKK Chan… - Science …, 2022 - science.org
Tumor innervation is a common phenomenon with unknown mechanism. Here, we
discovered a direct mechanism of tumor-associated macrophage (TAM) for promoting de …

Adult neurogenesis acts as a neural regularizer

LM Tran, A Santoro, L Liu… - Proceedings of the …, 2022 - National Acad Sciences
New neurons are continuously generated in the subgranular zone of the dentate gyrus
throughout adulthood. These new neurons gradually integrate into hippocampal circuits …

Ontogeny of adult neural stem cells in the mammalian brain

AM Bond, G Ming, H Song - Current topics in developmental biology, 2021 - Elsevier
Neural stem cells (NSCs) persist into adulthood in the subgranular zone (SGZ) of the
dentate gyrus in the hippocampus and in the ventricular-subventricular zone (V-SVZ) of the …

A Baldwin interpretation of adult hippocampal neurogenesis: from functional relevance to physiopathology

DN Abrous, M Koehl, M Lemoine - Molecular psychiatry, 2022 - nature.com
Hippocampal adult neurogenesis has been associated to many cognitive, emotional, and
behavioral functions and dysfunctions, and its status as a selected effect or an “appendix of …

Cognitive flexibility is selectively impaired by radiation and is associated with differential recruitment of adult-born neurons

EM Amelchenko, DV Bezriadnov… - Journal of …, 2023 - Soc Neuroscience
Exposure to elevated doses of ionizing radiation, such as those in therapeutic procedures,
catastrophic accidents, or space exploration, increases the risk of cognitive dysfunction. The …

Cell population dynamics in the course of adult hippocampal neurogenesis: Remaining unknowns

C Olpe, S Jessberger - Hippocampus, 2023 - Wiley Online Library
Neural stem cells (NSCs) generate new neurons throughout life in the mammalian
hippocampus. The distinct developmental steps in the course of adult neurogenesis …