Simple Summary Antibody-drug conjugates (ADC) are a rapidly expanding class of anti-
cancer drugs, with twelve agents in current clinical use. Despite recent successes, many …

Of the five immunoglobulin isotypes, immunoglobulin G (IgG) is most abundant in human
serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ …

IgG3 is unique among the IgG subclasses due to its extended hinge, allotypic diversity and
enhanced effector functions, including highly efficient pathogen neutralisation and …

B cells play a central role in the immunopathogenesis of glomerulonephritides and
transplant rejection. B cells secrete antibodies that contribute to tissue injury via multiple …

IgG3 comprises only a minor fraction of IgG and has remained relatively understudied until
recent years. Key physiochemical characteristics of IgG3 include an elongated hinge region …

The importance and effect of Fc glycosylation of monoclonal antibodies with regard to
biological activity is widely discussed and has been investigated in numerous studies. Fc …

Sindbis virus (SINV; family Togaviridae, genus Alphavirus) is an enveloped RNA virus
widely distributed in Eurasia, Africa, Oceania and Australia. SINV is transmitted among its …

Duchenne muscular dystrophy (DMD) is a progressive severe muscle‐wasting disease
caused by mutations in DMD, encoding dystrophin, that leads to loss of muscle function with …

Purpose: Alternative glycosylation has significant structural and functional consequences on
IgG and consequently also on cancer immunosurveillance. Because of technological …

The loss of tolerance to self-antigens is the unequivocal “red line” of autoimmunity: both
development of autoreactive T and B cells and production of polyclonal autoantibodies …