Exploring Smad5: a review to pave the way for a deeper understanding of the pathobiology of common respiratory diseases

Z Lin, J Zhuang, L He, S Zhu, W Kong, W Lu… - Molecular Medicine, 2024 - Springer
Smad5 (small mothers against decapentaplegic 5) protein is a receptor-regulated member
of the Smad family proteins, mainly participating in the bone morphogenetic protein (BMP) …

[HTML][HTML] The bmp pathway in blood vessel and lymphatic vessel biology

LC Ponomarev, J Ksiazkiewicz, MW Staring… - International Journal of …, 2021 - mdpi.com
Bone morphogenetic proteins (BMPs) were originally identified as the active components in
bone extracts that can induce ectopic bone formation. In recent decades, their key role has …

High-speed super-resolution imaging of rotationally symmetric structures using SPEED microscopy and 2D-to-3D transformation

Y Li, M Tingey, A Ruba, W Yang - Nature protocols, 2021 - nature.com
Various super-resolution imaging techniques have been developed to break the diffraction-
limited resolution of light microscopy. However, it still remains challenging to obtain three …

Dynamics of nuclear export of pre-ribosomal subunits revealed by high-speed single-molecule microscopy in live cells

SL Junod, M Tingey, JM Kelich, A Goryaynov… - Iscience, 2023 - cell.com
We present a study on the nuclear export efficiency and time of pre-ribosomal subunits in
live mammalian cells, using high-speed single-molecule tracking and single-molecule …

A TGFβR inhibitor represses keratin-7 expression in 3D cultures of human salivary gland progenitor cells

EW Fowler, EJ van Venrooy, RL Witt, X Jia - Scientific Reports, 2022 - nature.com
Salivary gland tissue engineering offers an attractive alternative for the treatment of radiation-
induced xerostomia. Key to the success of this approach is the maintenance and expansion …

Mad dephosphorylation at the nuclear pore is essential for asymmetric stem cell division

J Sardi, MB Bener, T Simao… - Proceedings of the …, 2021 - National Acad Sciences
Stem cells divide asymmetrically to generate a stem cell and a differentiating daughter cell.
Yet, it remains poorly understood how a stem cell and a differentiating daughter cell can …

PM2. 5 exposure inhibits osteoblast differentiation by increasing the ubiquitination and degradation of Smad4

J Yang, C Han, J Ye, X Hu, R Wang, J Shen, L Li, G Hu… - Toxicology Letters, 2024 - Elsevier
Increasing epidemiological evidence has shown that PM 2.5 exposure is significantly
associated with the occurrence of osteoporosis. It has been well demonstrated that PM 2.5 …

Mechanisms of TGFβ3 action as a therapeutic agent for promoting the synthesis of extracellular matrix proteins in hyaline cartilage

MS Bozhokin, YV Sopova, DV Kachkin, AA Rubel… - Biochemistry …, 2020 - Springer
Hyaline cartilage is a nonvascular connective tissue covering the joint surface. It consists
mostly of the extracellular matrix proteins and a small number of highly differentiated …

The role of thrombomodulin in modulating ITGB3 expression and its implications for triple‐negative breast cancer progression

YJ Chang, GMSH Prince, PL Wei… - Cell Biology …, 2024 - Wiley Online Library
Triple‐negative breast cancer (TNBC) is the most aggressive subtype of breast cancer (BC)
compared to other BC subtypes in clinical settings. Currently, there are no effective …

[HTML][HTML] Cellular Compartmentalization as a Physical Regulatory Mechanism of Signaling Pathways

AN Fayad, D Mazo-Durán, DG Míguez - Biophysica, 2024 - mdpi.com
Cells compartmentalize biochemical processes using physical barriers in the form of
membranes. Eukaryotes have a wide diversity of membrane-based compartments that can …