Human African trypanosomiasis, or sleeping sickness, is caused by infection with parasites
of the genus Trypanosoma, transmitted by the tsetse fly. The disease has two forms …

Infection and inflammation induce the acutephase response (APR), leading to multiple
alterations in lipid and lipoprotein metabolism. Plasma triglyceride levels increase from …

Parasitic protozoa are a major cause of global infectious disease. These eukaryotic
pathogens have evolved with the vertebrate immune system and typically produce long …

Haptoglobin (Hp) belongs to the family of acute-phase plasma proteins and represents the
most important plasma detoxifier of hemoglobin (Hb). The basic Hp molecule is a tetrameric …

ApolipoproteinL1 (APOL1) protects humans and some primates against several African
trypanosomes. APOL1 genetic variants strongly associated with kidney disease in African …

Salivarian trypanosomes are single cell extracellular parasites that cause infections in a
wide range of hosts. Most pathogenic infections worldwide are caused by one of four major …

Summary Apolipoprotein L1 (APOL1) genetic variants account for much of the excess risk of
chronic and end-stage kidney disease, which results in a significant global health disparity …

Plasma levels of high density lipoprotein cholesterol (HDL-C) have long been associated
with protection against cardiovascular disease (CVD) in large populations. However, HDL-C …

The protozoan parasite Trypanosoma brucei is lysed by apolipoprotein LI, a component of
human high-density lipoprotein (HDL) particles that are also characterized by the presence …

Abstract The African parasite Trypanosoma brucei gambiense accounts for 97% of human
sleeping sickness cases. T. b. gambiense resists the specific human innate immunity acting …