The main protease of SARS-CoV-2 (Mpro) is the most promising drug target against
coronaviruses due to its essential role in virus replication. With newly emerging variants …

In domain-swapping, two or more identical protein monomers exchange structural elements
and fold into dimers or multimers whose units are structurally similar to the original …

The unparalleled global effort to combat the continuing severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) pandemic over the last year has resulted in promising …

Viral protease inhibitors are remarkably effective at blocking the replication of viruses such
as human immunodeficiency virus and hepatitis C virus, but they inevitably lead to the …

The assembly of two monomeric constructs spanning segments 1-199 (MPro 1-199) and 10-
306 (MPro 10-306) of SARS-CoV-2 main protease (MPro) was examined to assess the …

The coronavirus disease pandemic caused by infection with the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has affected the global healthcare system. As low …

This manuscript details the application of Isothermal Titration Calorimetry (ITC) to
characterize the kinetics of 3CLpro, the main protease from the Severe Acute Respiratory …

Protein nanostructures have been gaining in interest, along with developments in new
methods for construction of novel nanostructures. We have previously shown that c-type …

The discovery of antiviral agents against SARS-CoV-2 is an important step toward ending
the COVID-19 pandemic and to tackle future outbreaks. In this context, the main protease (M …

Forkhead box P (FoxP) proteins are members of the versatile Fox transcription factors, which
control the timing and expression of multiple genes for eukaryotic cell homeostasis …