Targeting nucleotide metabolism can not only inhibit tumor initiation and progression but
also exert serious side effects. With in-depth studies of nucleotide metabolism, our …

The nucleolus is a large nuclear membraneless organelle responsible for ribosome
biogenesis. Ribosomes are cytoplasmic macromolecular complexes comprising RNA and …

Molecular subtypes of small cell lung cancer (SCLC) defined by the expression of key
transcription regulators have recently been proposed in cell lines and limited number of …

The MYC transcription factor, encoded by the c‐MYC proto‐oncogene, is activated by
growth‐promoting signals, and is a key regulator of biosynthetic and metabolic pathways …

Small cell lung cancer (SCLC) is a rapidly growing, highly metastatic, and relatively immune-
cold lung cancer subtype. Historically viewed in the laboratory and clinic as a single …

Access to clinically relevant small cell lung cancer (SCLC) tissue is limited because surgical
resection is rare in metastatic SCLC. Patient-derived xenografts (PDX) and circulating tumor …

Introduction The transcription factor MYC is overexpressed in 30% of small cell lung cancer
(SCLC) tumors and is known to modulate the balance between two major pathways of …

Physiological changes in GTP levels in live cells have never been considered a regulatory
step of RAC1 activation because intracellular GTP concentration (determined by …

Purine, an abundant substrate in organisms, is a critical raw material for cell proliferation
and an important factor for immune regulation. The purine de novo pathway and salvage …

Small cell lung carcinoma (SCLC) is characterized by high metastatic rate and poor
prognosis. The platinum-based chemotherapy still represents the backbone of the therapy; …