Pseudokinases are members of the protein kinase superfamily but signal primarily through
noncatalytic mechanisms. Many pseudokinases contribute to the pathologies of human …

Hypercholesterolemia is a strong determinant of mortality and morbidity associated with
cardiovascular diseases and a major contributor to the global disease burden. Mutations in …

The ongoing debate on whether non-alcoholic fatty liver disease (NAFLD) is an active
contributor or an innocent bystander in the development of cardiovascular disease (CVD) …

Ischemic heart disease is the main cause of death worldwide and is accelerated by
increased levels of low-density lipoprotein cholesterol (LDL-C). Proprotein convertase …

Advances in the understanding of the Tribbles family of pseudokinases (TRIB1, TRIB2 and
TRIB3) reveal these proteins as potentially valuable biomarkers of disease diagnosis …

Macrophages drive atherosclerotic plaque progression and rupture; hence, attenuating their
atherosclerosis-inducing properties holds promise for reducing coronary heart disease …

Background Present evidences suggested that TRIB1 rs17321515 polymorphism was tightly
associated with the increased risk of NAFLD and CHD. CHD is one of the main …

A novel class of RNA molecule emerged from human transcriptome sequencing studies
termed long non-coding RNAs. These RNA molecules differ from other classes of non …

The TRIB1 gene has been associated with multiple malignancies, plasma triglycerides and
coronary artery disease (CAD). Despite the clinical significance of this pseudo-kinase, there …

The TRIB1 locus has been linked to both cardiovascular disease and hepatic steatosis.
Recent efforts have revealed TRIB1 to be a major regulator of liver function, largely, but not …