Leukemia inhibitory factor (LIF)

NA Nicola, JJ Babon - Cytokine & growth factor reviews, 2015 - Elsevier
Leukemia inhibitory factor (LIF) is the most pleiotropic member of the interleukin-6 family of
cytokines. It utilises a receptor that consists of the LIF receptor β and gp130 and this receptor …

Ectopic pregnancy secondary to in vitro fertilisation-embryo transfer: pathogenic mechanisms and management strategies

B Refaat, E Dalton, WL Ledger - Reproductive Biology and Endocrinology, 2015 - Springer
Background Ectopic pregnancy (EP) is the leading cause of maternal morbidity and mortality
during the first trimester and the incidence increases dramatically with in vitro fertilisation …

Human blastocyst secreted microRNA regulate endometrial epithelial cell adhesion

C Cuman, M Van Sinderen, MP Gantier, K Rainczuk… - …, 2015 - thelancet.com
Successful embryo implantation requires synchronous development and communication
between the blastocyst and the endometrium, however the mechanisms of communication in …

Chronic Chlamydia infection in human organoids increases stemness and promotes age-dependent CpG methylation

M Kessler, K Hoffmann, K Fritsche, V Brinkmann… - Nature …, 2019 - nature.com
Chronic infections of the fallopian tubes with Chlamydia trachomatis (Ctr) cause scarring
and can lead to infertility. Here we use human fallopian tube organoids and genital Ctr …

[HTML][HTML] Tubal ectopic pregnancy occurrence is associated with high expressions of prokineticin receptors and aberrant secretion of inflammatory cytokines

L Ma, Z Li, S Xi, Q Guo, P Zhao, W Li, J Ai… - American Journal of …, 2020 - ncbi.nlm.nih.gov
Objective: Tubal ectopic pregnancy (TEP) remains the most common cause of maternal
morbidity and mortality in the early months of pregnancy. The aim of this study is to perform …

The long noncoding RNA PTENP1 regulates human endometrial epithelial adhesive capacity in vitro: implications in infertility

M Takamura, W Zhou, L Rombauts… - Biology of …, 2020 - academic.oup.com
There is general consensus that the synchronous development of the embryo and
endometrium is absolutely essential for successful implantation. Recent studies have …

Transcytosis of IL-11 and apical redirection of gp130 is mediated by IL-11α receptor

N Monhasery, J Moll, C Cuman, M Franke, L Lamertz… - Cell reports, 2016 - cell.com
Summary Interleukin (IL)-11 signaling is involved in various processes, including epithelial
intestinal cell regeneration and embryo implantation. IL-11 signaling is initiated upon …

Blocking endogenous leukemia inhibitory factor during placental development in mice leads to abnormal placentation and pregnancy loss

A Winship, J Correia, T Krishnan, E Menkhorst… - Scientific reports, 2015 - nature.com
The placenta forms the interface between the maternal and fetal circulation and is critical for
the establishment of a healthy pregnancy. Specialized trophoblast cells derived from the …

LIF upregulates poFUT1 expression and promotes trophoblast cell migration and invasion at the fetal–maternal interface

S Liu, J Wang, HM Qin, XM Yan, XS Yang, C Liu… - Cell death & …, 2014 - nature.com
Trophoblast cell migration and invasion are crucial for the establishment of a successful
pregnancy. Protein O-fucosyltransferases, such as poFUT1 and poFUT2, catalyze the O …

Leukemia inhibitory factor (LIF) inhibition during mid-gestation impairs trophoblast invasion and spiral artery remodelling during pregnancy in mice

A Winship, J Correia, JG Zhang, NA Nicola… - PLoS …, 2015 - journals.plos.org
The placenta forms the interface between the maternal and fetal circulation and is critical for
the establishment of a healthy pregnancy. Trophoblast cell proliferation, migration and …