It has long been known that phosphoinositides are present in cellular membranes, but only
in the past four decades has our understanding of their importance for proper cell function …

Phosphoinositides (PI) form just a minor portion of the total phospholipid content in cells but
are significantly involved in cancer development and progression. In several cancer types …

In this study, the differentiation of C2C12 cells, a primary line of murine myoblasts, was
investigated by a multiple technical approach. Undifferentiated cells, and those at …

The roles of phosphoinositide-specific phospholipase C (PLC) have been extensively
investigated in diverse cell lines and pathological conditions. Among the PLC isozmes …

Polyphosphoinositides (PPIns) are a family of seven lipid messengers that regulate a vast
array of signalling pathways to control cell proliferation, migration, survival and …

Background Human skeletal muscle stem cells are important for muscle regeneration.
However, the combined genome-wide DNA methylation and expression changes taking …

Abstract Phosphatidylinositol-5-phosphate (PtdIns5P)-4-kinases (PIP4Ks) are stress-
regulated lipid kinases that phosphorylate PtdIns5P to generate PtdIns (4, 5) P 2. There are …

Abstract Phosphoinositide-phospholipase C-β1 (PLC-β1) plays a crucial role in the initiation
of the genetic program responsible for muscle differentiation and osteogenesis. During …

Myelodysplastic syndrome (MDS) is an adult hematological disease that evolves into acute
myeloid leukemia (AML) in about 30% of the cases. The availability of a highly specific …

Phosphatidylinositol (PI) metabolism represents the core of a network of signaling pathways
which modulate many cellular functions including cell proliferation, cell differentiation …