Background Several new genes and clinical subtypes have been identified since the
publication in 2014 of the report of the last International Consensus Meeting on …

The epidermal nevus syndromes represent a group of distinct disorders that can be
distinguished by the type of associated epidermal nevus and by the criterion of presence or …

Epidermolysis bullosa (EB) is a heterogeneous group of rare inherited blistering skin
disorders characterized by skin fragility following minor trauma, usually present since birth …

Mosaic disorders can most easily be studied in the skin. This article presents a
comprehensive overview of the different forms of cutaneous mosaicism. Major categories …

Laminin 332 is an essential component of the dermal-epidermal junction, a highly
specialized basement membrane zone that attaches the epidermis to the dermis and …

Mosaicism denotes an individual who has at least two populations of cells with distinct
genotypes that are derived from a single fertilized egg. Genetic variation among the cell …

Genetic skin fragility manifests with diminished resistance of the skin and mucous
membranes to external mechanical forces and with skin blistering, erosions, and painful …

The cutaneous basement membrane zone (BMZ) is a highly specialized functional complex
that provides the skin with structural adhesion and resistance to shearing forces. Its …

The term epidermolysis bullosa (EB) refers to a group of hereditary skin blistering diseases.
The group is clinically and genetically heterogeneous, but all EB forms are associated with …

Epidermolysis bullosa (EB) encompasses a heterogeneous group of inherited skin fragility
disorders, with mutations in genes encoding the basement membrane zone (BMZ) proteins …