The renal medulla produces concentrated urine through the generation of an osmotic
gradient extending from the cortico-medullary boundary to the inner medullary tip. This …

▪ Abstract Urea plays a key role in the urine-concentrating mechanism. Physiologic and
molecular data demonstrate that urea transport in kidney and red blood cells occurs by …

To investigate the role of inner medullary collecting duct (IMCD) urea transporters in the
renal concentrating mechanism, we deleted 3 kb of the UT-A urea transporter gene …

Urea transporter UT-B has been proposed to be the major urea transporter in erythrocytes
and kidney-descending vasa recta. The mouse UT-B cDNA was isolated and encodes a 384 …

The rat renal urea transporter UT-A includes four isoforms. UT-A1, UT-A3, and UT-A4 are
transcribed from a single initiation site at the 5′-end of the gene; a distinct internal initiation …

Arginine vasopressin (AVP) is released from the posterior pituitary gland during states of
hyperosmolality or hypovolemia. AVP is a peptide hormone, with antidiuretic and …

The renal urea transporter gene (UT-A) produces different transcripts in the inner medullary
collecting ducts (UT-A1) and thin descending limbs of Henle's loop (UT-A2), coding for …

Since the turn of the 21st century, gene knockout mice have been created for all major urea
transporters that are expressed in the kidney: the collecting duct urea transporters UT-A1 …

Urea transport proteins were initially proposed to exist in the kidney in the late 1980s when
studies of urea permeability revealed values in excess of those predicted by simple lipid …

Urea transporters (UTs) belonging to the solute carrier 14 (SLC14) family comprise two
genes with a total of eight isoforms in mammals, UT-A1 to-A6 encoded by SLC14A2 and UT …