Nearly 30 hereditary disorders in humans result from an increase in the number of copies of
simple repeats in genomic DNA. These DNA repeats seem to be predisposed to such …

Repeated elements can be widely abundant in eukaryotic genomes, composing more than
50% of the human genome, for example. It is possible to classify repeated sequences into …

Adult-onset cerebellar ataxias are a group of neurodegenerative conditions that challenge
both genetic discovery and molecular diagnosis. In this study, we identified an intronic (GAA) …

An expanded GGGGCC repeat in C9orf72 is the most common genetic cause of
frontotemporal dementia and amyotrophic lateral sclerosis. A fundamental question is …

DNA becomes single stranded (ssDNA) during replication, transcription, and repair.
Transiently formed ssDNA segments can adopt alternative conformations, including …

The factors driving or preventing pathological expansion of tandem repeats remain largely
unknown. Here, we assessed the FGF14 (GAA)·(TTC) repeat locus in 2,530 individuals by …

The expansion of repeated sequences is the cause of over 30 inherited genetic diseases,
including Huntington disease, myotonic dystrophy (types 1 and 2), fragile X syndrome, many …

Background Many neurodegenerative diseases are caused by nucleotide repeat
expansions, but most expansions, like the C9orf72 'GGGGCC'(G 4 C 2) repeat that causes …

DNA forms not only the canonical duplex structure but also non-canonical structures. Most
potential sequences that induce the formation of non-canonical structures are present in …

Substantial progress has been realized in the past several years in our understanding of the
molecular mechanisms responsible for the expansions and deletions (genetic instabilities) …