CREB and its close relatives are now widely accepted as prototypical stimulus-inducible
transcription factors. In many cell types, these factors function as effector molecules that …

Neuronal activity can lead to marked increases in the concentration of cytosolic calcium,
which then functions as a second messenger that mediates a wide range of cellular …

Cells adopt highly polarized shapes and form distinct subcellular compartments in many
cases due to the localization of many mRNAs to specific areas, where they are translated …

cAMP (3′, 5′ cyclic adenosine monophosphate) is a second messenger that in eukaryotic
cells induces physiological responses ranging from growth, differentiation, and gene …

To explore the role of protein kinase A (PKA) in the late phase of long-term potentiation (L-
LTP) and memory, we generated transgenic mice that express R (AB), an inhibitory form of …

Adenylyl cyclases (ACs) generate the second messenger cAMP from ATP. Mammalian cells
express nine transmembrane AC (mAC) isoforms (AC1–9) and a soluble AC (sAC, also …

At least nine closely related isoforms of adenylyl cyclases (ACs), the enzymes responsible
for the synthesis of cyclic AMP (cAMP) from ATP, have been cloned and characterized in …

Although Ca 2+-stimulated cAMP response element binding protein–(CREB-) dependent
transcription has been implicated in growth, differentiation, and neuroplasticity, mechanisms …

Stimulus-secretion coupling is an essential process in secretory cells in which regulated
exocytosis occurs, including neuronal, neuroendocrine, endocrine, and exocrine cells. While …

Gene expression changes in the brain affect cognition during normal and pathological
aging. Progress in understanding the cellular processes regulating gene expression …